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- W2080185181 endingPage "515" @default.
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- W2080185181 abstract "Determination of the chiral composition of drugs is nowadays a key step in order to determine purity, activity, bioavailability, biodegradation, etc., of pharmaceuticals. In this article, works published for the last 5 years on the analysis of chiral drugs by liquid separation techniques coupled with mass spectrometry are reviewed. Namely, chiral analysis of pharmaceuticals including, e.g., antiinflammatories, antihypertensives, relaxants, etc., by liquid chromatography–mass spectrometry and capillary electrophoresis–mass spectrometry are included. The importance and interest of the analysis of the enantiomers of the active compound and its metabolites in different biological fluids (plasma, urine, cerebrospinal fluid, etc.) are also discussed." @default.
- W2080185181 created "2016-06-24" @default.
- W2080185181 creator A5048148334 @default.
- W2080185181 creator A5057342981 @default.
- W2080185181 date "2006-02-01" @default.
- W2080185181 modified "2023-09-26" @default.
- W2080185181 title "Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids" @default.
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- W2080185181 doi "https://doi.org/10.1016/j.jpba.2005.10.044" @default.
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