FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080202466> ?p ?o ?g. }

• W2080202466 endingPage "2212" @default.
• W2080202466 startingPage "2204" @default.
• W2080202466 abstract "Antimicrobial peptides (AMPs) secreted by the innate immune system are prevalent as the effective first-line of defense to overcome recurring microbial invasions. They have been widely accepted as the blueprints for the development of new antimicrobial agents for the treatment of drug resistant infections. However, there is also a growing concern that AMPs with a sequence that is too close to the host organism's AMP may inevitably compromise its own natural defense. In this study, we design a series of synthetic (non-natural) short α-helical AMPs to expand the arsenal of the AMP families and to gain further insights on their antimicrobial activities. These cationic and amphiphilic peptides have a general sequence of (XXYY)(n) (X: hydrophobic residue, Y: cationic residue, and n: the number of repeat units), and are designed to mimic the folding behavior of the naturally-occurring α-helical AMPs. The synthetic α-helical AMPs with 3 repeat units, (FFRR)(3), (LLRR)(3), and (LLKK)(3), are found to be more selective towards microbial cells than rat red blood cells, with minimum inhibitory concentration (MIC) values that are more than 10 times lower than their 50% hemolytic concentrations (HC(50)). They are effective against Gram-positive B. subtilis and yeast C. albicans; and the studies using scanning electron microscopy (SEM) have elucidated that these peptides possess membrane-lytic activities against microbial cells. Furthermore, non-specific immune stimulation assays of a typical peptide shows negligible IFN-α, IFN-γ, and TNF-α inductions in human peripheral blood mononuclear cells, which implies additional safety aspects of the peptide for both systemic and topical use. Therefore, the peptides designed in this study can be promising antimicrobial agents against the frequently-encountered Gram-positive bacteria- or yeast-induced infections." @default.
• W2080202466 created "2016-06-24" @default.
• W2080202466 creator A5011372519 @default.
• W2080202466 creator A5030676696 @default.
• W2080202466 creator A5046543918 @default.
• W2080202466 creator A5049475925 @default.
• W2080202466 creator A5061928018 @default.
• W2080202466 creator A5074166966 @default.
• W2080202466 date "2011-03-01" @default.
• W2080202466 modified "2023-10-12" @default.
• W2080202466 title "Synthetic cationic amphiphilic α-helical peptides as antimicrobial agents" @default.
• W2080202466 cites W1543277803 @default.
• W2080202466 cites W1963709456 @default.
• W2080202466 cites W1971040914 @default.
• W2080202466 cites W1978735135 @default.
• W2080202466 cites W1984679573 @default.
• W2080202466 cites W1987348853 @default.
• W2080202466 cites W1992603413 @default.
• W2080202466 cites W1992762269 @default.
• W2080202466 cites W1995033884 @default.
• W2080202466 cites W1995791421 @default.
• W2080202466 cites W1997152791 @default.
• W2080202466 cites W2003897459 @default.
• W2080202466 cites W2004455414 @default.
• W2080202466 cites W2005370852 @default.
• W2080202466 cites W2016858569 @default.
• W2080202466 cites W2020673265 @default.
• W2080202466 cites W2024854259 @default.
• W2080202466 cites W2026600362 @default.
• W2080202466 cites W2031620423 @default.
• W2080202466 cites W2044192034 @default.
• W2080202466 cites W2052462716 @default.
• W2080202466 cites W2054602599 @default.
• W2080202466 cites W2080165498 @default.
• W2080202466 cites W2083183071 @default.
• W2080202466 cites W2093352344 @default.
• W2080202466 cites W2094847571 @default.
• W2080202466 cites W2106596027 @default.
• W2080202466 cites W2106613961 @default.
• W2080202466 cites W2108305786 @default.
• W2080202466 cites W2112340256 @default.
• W2080202466 cites W2115622227 @default.
• W2080202466 cites W2123751639 @default.
• W2080202466 cites W2126719129 @default.
• W2080202466 cites W2166290770 @default.
• W2080202466 cites W2167815042 @default.
• W2080202466 cites W2188776897 @default.
• W2080202466 cites W2313275058 @default.
• W2080202466 cites W2898532680 @default.
• W2080202466 cites W4230736766 @default.
• W2080202466 cites W1983786493 @default.
• W2080202466 doi "https://doi.org/10.1016/j.biomaterials.2010.11.054" @default.
• W2080202466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21168911" @default.
• W2080202466 hasPublicationYear "2011" @default.
• W2080202466 type Work @default.
• W2080202466 sameAs 2080202466 @default.
• W2080202466 citedByCount "168" @default.
• W2080202466 countsByYear W20802024662012 @default.
• W2080202466 countsByYear W20802024662013 @default.
• W2080202466 countsByYear W20802024662014 @default.
• W2080202466 countsByYear W20802024662015 @default.
• W2080202466 countsByYear W20802024662016 @default.
• W2080202466 countsByYear W20802024662017 @default.
• W2080202466 countsByYear W20802024662018 @default.
• W2080202466 countsByYear W20802024662019 @default.
• W2080202466 countsByYear W20802024662020 @default.
• W2080202466 countsByYear W20802024662021 @default.
• W2080202466 countsByYear W20802024662022 @default.
• W2080202466 countsByYear W20802024662023 @default.
• W2080202466 crossrefType "journal-article" @default.
• W2080202466 hasAuthorship W2080202466A5011372519 @default.
• W2080202466 hasAuthorship W2080202466A5030676696 @default.
• W2080202466 hasAuthorship W2080202466A5046543918 @default.
• W2080202466 hasAuthorship W2080202466A5049475925 @default.
• W2080202466 hasAuthorship W2080202466A5061928018 @default.
• W2080202466 hasAuthorship W2080202466A5074166966 @default.
• W2080202466 hasConcept C136449434 @default.
• W2080202466 hasConcept C15920480 @default.
• W2080202466 hasConcept C170493617 @default.
• W2080202466 hasConcept C178790620 @default.
• W2080202466 hasConcept C185592680 @default.
• W2080202466 hasConcept C203014093 @default.
• W2080202466 hasConcept C2779281246 @default.
• W2080202466 hasConcept C4937899 @default.
• W2080202466 hasConcept C521977710 @default.
• W2080202466 hasConcept C540938839 @default.
• W2080202466 hasConcept C55493867 @default.
• W2080202466 hasConcept C67407626 @default.
• W2080202466 hasConcept C86803240 @default.
• W2080202466 hasConcept C8891405 @default.
• W2080202466 hasConcept C89423630 @default.
• W2080202466 hasConceptScore W2080202466C136449434 @default.
• W2080202466 hasConceptScore W2080202466C15920480 @default.
• W2080202466 hasConceptScore W2080202466C170493617 @default.
• W2080202466 hasConceptScore W2080202466C178790620 @default.
• W2080202466 hasConceptScore W2080202466C185592680 @default.
• W2080202466 hasConceptScore W2080202466C203014093 @default.
• W2080202466 hasConceptScore W2080202466C2779281246 @default.

• next