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- W2080203009 abstract "Endocrine therapies have been used for more than a century to treat breast cancer. A huge body of evidence from preclinical and clinical studies substantiates the outstanding role of estrogens in initiation and in promotion of almost two-thirds of breast cancer [1, 2]. Since the initial observations of Beatson who, in 1896 reported of dramatic tumor responses after bilateral oophorectomy in premenopausal women with advanced breast cancer, the suppression of the estrogen activity has represented the rationale for the manipulations aimed to affect the growth of breast cancer [3, 4]. Initially, surgical procedures as oophorectomy and adrenalectomy were shown to induce some tumor regression; since then, the development of drugs which negatively affect the production and/or the activity of estrogens led to a widespread use of hormonal manipulations [4]." @default.
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- W2080203009 date "2002-10-01" @default.
- W2080203009 modified "2023-10-16" @default.
- W2080203009 title "Endocrine therapy of breast cancer" @default.
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- W2080203009 doi "https://doi.org/10.1093/annonc/mdf640" @default.
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