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• W2080203492 abstract "The New Zealand native frogs, family Leiopelmatidae, are among the most archaic in the world. Leiopelma hochstetteri (Hochstetter's frog) is a small, semi-aquatic frog with numerous, fragmented populations scattered across New Zealand's North Island. We characterized a major histocompatibility complex (MHC) class II B gene (DAB) in L. hochstetteri from a spleen transcriptome, and then compared its diversity to neutral microsatellite markers to assess the adaptive genetic diversity of five populations (evolutionarily significant units, ESUs).L. hochstetteri possessed very high MHC diversity, with 74 DAB alleles characterized. Extremely high differentiation was observed at the DAB locus, with only two alleles shared between populations, a pattern that was not reflected in the microsatellites. Clustering analysis on putative peptide binding residues of the DAB alleles indicated four functional supertypes, all of which were represented in 4 of 5 populations, albeit at different frequencies. Otawa was an exception to these observations, with only two DAB alleles present.This study of MHC diversity highlights extreme population differentiation at this functional locus. Supertype differentiation was high among populations, suggesting spatial and/or temporal variation in selection pressures. Low DAB diversity in Otawa may limit this population's adaptive potential to future pathogenic challenges." @default.
• W2080203492 created "2016-06-24" @default.
• W2080203492 creator A5000708494 @default.
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• W2080203492 date "2015-04-13" @default.
• W2080203492 modified "2023-10-18" @default.
• W2080203492 title "Selection on MHC class II supertypes in the New Zealand endemic Hochstetter’s frog" @default.
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• W2080203492 doi "https://doi.org/10.1186/s12862-015-0342-0" @default.
• W2080203492 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4415247" @default.
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