FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080203963> ?p ?o ?g. }

• W2080203963 endingPage "e87697" @default.
• W2080203963 startingPage "e87697" @default.
• W2080203963 abstract "The intrahepatic cholestasis of pregnancy (ICP) is a multifactorial liver disorder which pathogenesis involves the interplay among abnormal bile acid (BA) levels, sex hormones, environmental factors, and genetic susceptibility. The dynamic nature of ICP that usually resolves soon after delivery suggests the possibility that its pathobiology is under epigenetic modulation. We explored the status of white blood peripheral cells-DNA methylation of CpG-enriched sites at the promoter of targeted genes (FXR/NR1H4, PXR/NR1I2, NR1I3, ESR1, and ABCC2) in a sample of 88 ICP patients and 173 healthy pregnant women in the third trimester of their pregnancies. CpG dinucleotides at the gene promoter of nuclear receptors subfamily 1 members and ABCC2 transporter were highly methylated during healthy pregnancy. We observed significant differences at the distal (−1890) and proximal promoter (−358) CpG sites of the FXR/NR1H4 and at the distal PXR/NR1I2 (−1224) promoter, which were consistently less methylated in ICP cases when compared with controls. In addition, we observed that methylation at FXR/NR1H4-1890 and PXR/NR1I2-1224 promoter sites was highly and positively correlated with BA profiling, particularly, conjugated BAs. Conversely, methylation level at the proximal FXR/NR1H4-358 CpG site was significantly and negatively correlated with the primary cholic and secondary deoxycholic acid. In vitro exploration showed that epiallopregnanolone sulfate, a reported FXR inhibitor, regulates the transcriptional activity of FXR/NR1H4 but seems to be not involved in the methylation changes. In conclusion, the identification of epigenetic marks in target genes provides a basis for the understanding of adverse liver-related pregnancy outcomes, including ICP." @default.
• W2080203963 created "2016-06-24" @default.
• W2080203963 creator A5014278453 @default.
• W2080203963 creator A5020854952 @default.
• W2080203963 creator A5026665802 @default.
• W2080203963 creator A5035354017 @default.
• W2080203963 creator A5041432155 @default.
• W2080203963 creator A5041535673 @default.
• W2080203963 creator A5042474807 @default.
• W2080203963 creator A5042513926 @default.
• W2080203963 date "2014-01-31" @default.
• W2080203963 modified "2023-10-18" @default.
• W2080203963 title "Promoter DNA Methylation of Farnesoid X Receptor and Pregnane X Receptor Modulates the Intrahepatic Cholestasis of Pregnancy Phenotype" @default.
• W2080203963 cites W1787537093 @default.
• W2080203963 cites W1967008993 @default.
• W2080203963 cites W1983745741 @default.
• W2080203963 cites W1986540119 @default.
• W2080203963 cites W1995503823 @default.
• W2080203963 cites W2002762124 @default.
• W2080203963 cites W2012279815 @default.
• W2080203963 cites W2031188909 @default.
• W2080203963 cites W2032693719 @default.
• W2080203963 cites W2033382529 @default.
• W2080203963 cites W2034819949 @default.
• W2080203963 cites W2035142208 @default.
• W2080203963 cites W2040253677 @default.
• W2080203963 cites W2042467203 @default.
• W2080203963 cites W2055898569 @default.
• W2080203963 cites W2057905778 @default.
• W2080203963 cites W2066748569 @default.
• W2080203963 cites W2067841793 @default.
• W2080203963 cites W2087079130 @default.
• W2080203963 cites W2090941249 @default.
• W2080203963 cites W2098905875 @default.
• W2080203963 cites W2100100424 @default.
• W2080203963 cites W2102459969 @default.
• W2080203963 cites W2121957461 @default.
• W2080203963 cites W2125168178 @default.
• W2080203963 cites W2159164310 @default.
• W2080203963 cites W2161224665 @default.
• W2080203963 cites W2162119791 @default.
• W2080203963 cites W2493590780 @default.
• W2080203963 doi "https://doi.org/10.1371/journal.pone.0087697" @default.
• W2080203963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3909199" @default.
• W2080203963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24498169" @default.
• W2080203963 hasPublicationYear "2014" @default.
• W2080203963 type Work @default.
• W2080203963 sameAs 2080203963 @default.
• W2080203963 citedByCount "15" @default.
• W2080203963 countsByYear W20802039632014 @default.
• W2080203963 countsByYear W20802039632015 @default.
• W2080203963 countsByYear W20802039632016 @default.
• W2080203963 countsByYear W20802039632017 @default.
• W2080203963 countsByYear W20802039632018 @default.
• W2080203963 countsByYear W20802039632020 @default.
• W2080203963 countsByYear W20802039632021 @default.
• W2080203963 countsByYear W20802039632022 @default.
• W2080203963 countsByYear W20802039632023 @default.
• W2080203963 crossrefType "journal-article" @default.
• W2080203963 hasAuthorship W2080203963A5014278453 @default.
• W2080203963 hasAuthorship W2080203963A5020854952 @default.
• W2080203963 hasAuthorship W2080203963A5026665802 @default.
• W2080203963 hasAuthorship W2080203963A5035354017 @default.
• W2080203963 hasAuthorship W2080203963A5041432155 @default.
• W2080203963 hasAuthorship W2080203963A5041535673 @default.
• W2080203963 hasAuthorship W2080203963A5042474807 @default.
• W2080203963 hasAuthorship W2080203963A5042513926 @default.
• W2080203963 hasBestOaLocation W20802039631 @default.
• W2080203963 hasConcept C104317684 @default.
• W2080203963 hasConcept C121608353 @default.
• W2080203963 hasConcept C126322002 @default.
• W2080203963 hasConcept C132040763 @default.
• W2080203963 hasConcept C134018914 @default.
• W2080203963 hasConcept C140173407 @default.
• W2080203963 hasConcept C150194340 @default.
• W2080203963 hasConcept C172313692 @default.
• W2080203963 hasConcept C172680121 @default.
• W2080203963 hasConcept C190727270 @default.
• W2080203963 hasConcept C193264327 @default.
• W2080203963 hasConcept C203862802 @default.
• W2080203963 hasConcept C2779224579 @default.
• W2080203963 hasConcept C2779234561 @default.
• W2080203963 hasConcept C2779399885 @default.
• W2080203963 hasConcept C33288867 @default.
• W2080203963 hasConcept C41091548 @default.
• W2080203963 hasConcept C502942594 @default.
• W2080203963 hasConcept C530470458 @default.
• W2080203963 hasConcept C54355233 @default.
• W2080203963 hasConcept C63932345 @default.
• W2080203963 hasConcept C71924100 @default.
• W2080203963 hasConcept C84606932 @default.
• W2080203963 hasConcept C86339819 @default.
• W2080203963 hasConcept C86803240 @default.
• W2080203963 hasConceptScore W2080203963C104317684 @default.
• W2080203963 hasConceptScore W2080203963C121608353 @default.
• W2080203963 hasConceptScore W2080203963C126322002 @default.
• W2080203963 hasConceptScore W2080203963C132040763 @default.
• W2080203963 hasConceptScore W2080203963C134018914 @default.

• next