FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080204807> ?p ?o ?g. }

• W2080204807 endingPage "4209" @default.
• W2080204807 startingPage "4209" @default.
• W2080204807 abstract "To determine the effects of silencing Toll-like receptor (TLR) 9 signaling in Pseudomonas aeruginosa keratitis.Corneal TLR9 mRNA levels were tested by RT-PCR in C57BL/6 (B6, susceptible) and BALB/c (resistant) mice and compared. The response of B6 mice to CpG DNA, which binds TLR9, was tested after subconjunctival injection of mice with control or CpG DNA; TLR9, IL-1beta, macrophage inflammatory protein (MIP)-2, IL-4, IL-10, IL-12, IL-18, and IFN-gamma levels were measured by RT-PCR. Langerhans cells (LCs) were stimulated with CpG DNA and treated with TLR9 or control siRNA, and mRNA levels of TLR9, IL-1beta, and MIP-2 were detected by RT-PCR. In addition, IL-1beta levels were tested by ELISA. Then B6 mice were injected subconjunctivally with control or TLR9 siRNA before infection and treated topically afterward. Slit lamp, clinical score, RT-PCR, ELISA, myeloperoxidase assay, and plate counts were performed.TLR9 mRNA levels were sixfold higher in B6 than in BALB/c corneas the day after injection. B6 mice injected with CpG DNA exhibited an increase in corneal mRNA for TLR9, IL-1beta, MIP-2, IL-12, and IFN-gamma over controls. LCs stimulated with CpG DNA and treated with TLR9 siRNA exhibited reduced TLR9, IL-1beta, and MIP-2 levels compared with controls. Finally, B6 mice treated with TLR9 siRNA showed decreases in corneal opacity, polymorphonuclear leukocyte number, IL-12 and IFN-gamma mRNA, IL-1beta, and MIP-2 protein compared with those treated with control siRNA. Fewer corneas perforated in these mice, but bacterial loads were higher than in controls.Signaling through TLR9 appears important in P. aeruginosa keratitis, and silencing TLR9 signaling reduces inflammation but likely contributes to decreased bacterial killing in the cornea." @default.
• W2080204807 created "2016-06-24" @default.
• W2080204807 creator A5053675854 @default.
• W2080204807 creator A5053731641 @default.
• W2080204807 creator A5063834104 @default.
• W2080204807 creator A5087787304 @default.
• W2080204807 date "2005-11-01" @default.
• W2080204807 modified "2023-10-12" @default.
• W2080204807 title "Silencing Toll-like Receptor-9 in<i>Pseudomonas aeruginosa</i>Keratitis" @default.
• W2080204807 cites W1011898118 @default.
• W2080204807 cites W1512963321 @default.
• W2080204807 cites W1514540900 @default.
• W2080204807 cites W1536674483 @default.
• W2080204807 cites W155277747 @default.
• W2080204807 cites W1680952474 @default.
• W2080204807 cites W1805681402 @default.
• W2080204807 cites W1840611749 @default.
• W2080204807 cites W1930598094 @default.
• W2080204807 cites W1974303227 @default.
• W2080204807 cites W1986564074 @default.
• W2080204807 cites W1991977041 @default.
• W2080204807 cites W1996120614 @default.
• W2080204807 cites W1997839876 @default.
• W2080204807 cites W1999070120 @default.
• W2080204807 cites W2000022183 @default.
• W2080204807 cites W2019039210 @default.
• W2080204807 cites W2020922034 @default.
• W2080204807 cites W2020923434 @default.
• W2080204807 cites W2045384882 @default.
• W2080204807 cites W2057237586 @default.
• W2080204807 cites W2069981713 @default.
• W2080204807 cites W2072543946 @default.
• W2080204807 cites W2074121683 @default.
• W2080204807 cites W2078900016 @default.
• W2080204807 cites W2083829960 @default.
• W2080204807 cites W2093934354 @default.
• W2080204807 cites W2097131232 @default.
• W2080204807 cites W2102068103 @default.
• W2080204807 cites W2110716288 @default.
• W2080204807 cites W2116417286 @default.
• W2080204807 cites W2117761826 @default.
• W2080204807 cites W2126397566 @default.
• W2080204807 cites W2131144171 @default.
• W2080204807 cites W2135874498 @default.
• W2080204807 cites W2140440263 @default.
• W2080204807 cites W2145078103 @default.
• W2080204807 cites W2146750081 @default.
• W2080204807 cites W2158423656 @default.
• W2080204807 cites W2160719127 @default.
• W2080204807 cites W2164578725 @default.
• W2080204807 cites W2172210601 @default.
• W2080204807 cites W2185008533 @default.
• W2080204807 cites W2188274605 @default.
• W2080204807 cites W93182134 @default.
• W2080204807 doi "https://doi.org/10.1167/iovs.05-0185" @default.
• W2080204807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16249500" @default.
• W2080204807 hasPublicationYear "2005" @default.
• W2080204807 type Work @default.
• W2080204807 sameAs 2080204807 @default.
• W2080204807 citedByCount "89" @default.
• W2080204807 countsByYear W20802048072012 @default.
• W2080204807 countsByYear W20802048072013 @default.
• W2080204807 countsByYear W20802048072014 @default.
• W2080204807 countsByYear W20802048072015 @default.
• W2080204807 countsByYear W20802048072017 @default.
• W2080204807 countsByYear W20802048072018 @default.
• W2080204807 countsByYear W20802048072019 @default.
• W2080204807 countsByYear W20802048072020 @default.
• W2080204807 countsByYear W20802048072021 @default.
• W2080204807 countsByYear W20802048072022 @default.
• W2080204807 countsByYear W20802048072023 @default.
• W2080204807 crossrefType "journal-article" @default.
• W2080204807 hasAuthorship W2080204807A5053675854 @default.
• W2080204807 hasAuthorship W2080204807A5053731641 @default.
• W2080204807 hasAuthorship W2080204807A5063834104 @default.
• W2080204807 hasAuthorship W2080204807A5087787304 @default.
• W2080204807 hasBestOaLocation W20802048071 @default.
• W2080204807 hasConcept C104317684 @default.
• W2080204807 hasConcept C105580179 @default.
• W2080204807 hasConcept C119056186 @default.
• W2080204807 hasConcept C140173407 @default.
• W2080204807 hasConcept C150194340 @default.
• W2080204807 hasConcept C153911025 @default.
• W2080204807 hasConcept C170493617 @default.
• W2080204807 hasConcept C185592680 @default.
• W2080204807 hasConcept C190727270 @default.
• W2080204807 hasConcept C203014093 @default.
• W2080204807 hasConcept C22801619 @default.
• W2080204807 hasConcept C2779138994 @default.
• W2080204807 hasConcept C2908999202 @default.
• W2080204807 hasConcept C48023723 @default.
• W2080204807 hasConcept C55493867 @default.
• W2080204807 hasConcept C86803240 @default.
• W2080204807 hasConceptScore W2080204807C104317684 @default.
• W2080204807 hasConceptScore W2080204807C105580179 @default.
• W2080204807 hasConceptScore W2080204807C119056186 @default.
• W2080204807 hasConceptScore W2080204807C140173407 @default.
• W2080204807 hasConceptScore W2080204807C150194340 @default.

• next