FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080206255> ?p ?o ?g. }

• W2080206255 endingPage "2835" @default.
• W2080206255 startingPage "2825" @default.
• W2080206255 abstract "Mesenchymal stem cells (MSCs) have potent immunosuppressive effects in vitro and are considered as a therapeutic option for autoimmune disease and organ transplantation. While MSCs show beneficial effects on immune disease progression and transplant survival in animal models, the immunomodulatory mechanisms involved are largely unknown. In the present study, we show that intravenously infused C57BL/6- green fluorescent protein (GFP) MSCs home to the lungs in C57BL/6 recipient mice and induce an inflammatory response. This response was characterized by increased mRNA expression of monocyte chemoattractant protein-1 (MCP1), IL1-β, and TNF-α and an increase in macrophages in lung tissue 2 h after MSC infusion. Simultaneously, serum levels of proinflammatory IL6, CXCL1, and MCP1 protein increased, demonstrating systemic immune activation after MSC infusion. In liver tissue, no C57BL/6-GFP MSCs were detected, but MCP1 and TNF-α mRNA levels peaked 4 h after MSC infusion. The expression of the anti-inflammatory cytokines TGF-β, IL4, and IL10 was only marginally affected. Nevertheless, 3 days after MSC infusion, animals developed a milder inflammatory response to lipopolysaccharides. Our results suggest that the in vivo immunomodulatory effects of MSCs originate from an inflammatory response that is induced by the infusion of MSCs, which is followed by a phase of reduced immune reactivity." @default.
• W2080206255 created "2016-06-24" @default.
• W2080206255 creator A5000967515 @default.
• W2080206255 creator A5001674274 @default.
• W2080206255 creator A5011538150 @default.
• W2080206255 creator A5019473153 @default.
• W2080206255 creator A5036151518 @default.
• W2080206255 creator A5044567914 @default.
• W2080206255 creator A5046825964 @default.
• W2080206255 creator A5061960308 @default.
• W2080206255 creator A5065236703 @default.
• W2080206255 creator A5089542580 @default.
• W2080206255 date "2013-11-01" @default.
• W2080206255 modified "2023-10-18" @default.
• W2080206255 title "Mesenchymal Stem Cells Induce an Inflammatory Response After Intravenous Infusion" @default.
• W2080206255 cites W1508798545 @default.
• W2080206255 cites W1537104679 @default.
• W2080206255 cites W1968255500 @default.
• W2080206255 cites W1976371737 @default.
• W2080206255 cites W1980427717 @default.
• W2080206255 cites W1995499825 @default.
• W2080206255 cites W1999360673 @default.
• W2080206255 cites W2011653132 @default.
• W2080206255 cites W2019495971 @default.
• W2080206255 cites W2024971445 @default.
• W2080206255 cites W2028239901 @default.
• W2080206255 cites W2038022281 @default.
• W2080206255 cites W2038961626 @default.
• W2080206255 cites W2039751388 @default.
• W2080206255 cites W2045080708 @default.
• W2080206255 cites W2062787672 @default.
• W2080206255 cites W2066284148 @default.
• W2080206255 cites W2069006548 @default.
• W2080206255 cites W2093734223 @default.
• W2080206255 cites W2105734762 @default.
• W2080206255 cites W2106117542 @default.
• W2080206255 cites W2107065228 @default.
• W2080206255 cites W2112527416 @default.
• W2080206255 cites W2115788075 @default.
• W2080206255 cites W2118574411 @default.
• W2080206255 cites W2118969721 @default.
• W2080206255 cites W2137142305 @default.
• W2080206255 cites W2138946470 @default.
• W2080206255 cites W2150953486 @default.
• W2080206255 cites W2151847306 @default.
• W2080206255 cites W2155044423 @default.
• W2080206255 cites W2159358845 @default.
• W2080206255 cites W2159999899 @default.
• W2080206255 cites W2166050879 @default.
• W2080206255 cites W2166106062 @default.
• W2080206255 cites W2166285548 @default.
• W2080206255 cites W2169367453 @default.
• W2080206255 doi "https://doi.org/10.1089/scd.2013.0193" @default.
• W2080206255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23767885" @default.
• W2080206255 hasPublicationYear "2013" @default.
• W2080206255 type Work @default.
• W2080206255 sameAs 2080206255 @default.
• W2080206255 citedByCount "102" @default.
• W2080206255 countsByYear W20802062552013 @default.
• W2080206255 countsByYear W20802062552014 @default.
• W2080206255 countsByYear W20802062552015 @default.
• W2080206255 countsByYear W20802062552016 @default.
• W2080206255 countsByYear W20802062552017 @default.
• W2080206255 countsByYear W20802062552018 @default.
• W2080206255 countsByYear W20802062552019 @default.
• W2080206255 countsByYear W20802062552020 @default.
• W2080206255 countsByYear W20802062552021 @default.
• W2080206255 countsByYear W20802062552022 @default.
• W2080206255 countsByYear W20802062552023 @default.
• W2080206255 crossrefType "journal-article" @default.
• W2080206255 hasAuthorship W2080206255A5000967515 @default.
• W2080206255 hasAuthorship W2080206255A5001674274 @default.
• W2080206255 hasAuthorship W2080206255A5011538150 @default.
• W2080206255 hasAuthorship W2080206255A5019473153 @default.
• W2080206255 hasAuthorship W2080206255A5036151518 @default.
• W2080206255 hasAuthorship W2080206255A5044567914 @default.
• W2080206255 hasAuthorship W2080206255A5046825964 @default.
• W2080206255 hasAuthorship W2080206255A5061960308 @default.
• W2080206255 hasAuthorship W2080206255A5065236703 @default.
• W2080206255 hasAuthorship W2080206255A5089542580 @default.
• W2080206255 hasConcept C126322002 @default.
• W2080206255 hasConcept C13373296 @default.
• W2080206255 hasConcept C150903083 @default.
• W2080206255 hasConcept C164027704 @default.
• W2080206255 hasConcept C17991360 @default.
• W2080206255 hasConcept C187316574 @default.
• W2080206255 hasConcept C198826908 @default.
• W2080206255 hasConcept C203014093 @default.
• W2080206255 hasConcept C207001950 @default.
• W2080206255 hasConcept C2776914184 @default.
• W2080206255 hasConcept C2778754761 @default.
• W2080206255 hasConcept C2781184567 @default.
• W2080206255 hasConcept C2911091166 @default.
• W2080206255 hasConcept C71924100 @default.
• W2080206255 hasConcept C86803240 @default.
• W2080206255 hasConcept C8891405 @default.
• W2080206255 hasConcept C95444343 @default.
• W2080206255 hasConcept C96525457 @default.

• next