Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080206544> ?p ?o ?g. }
- W2080206544 abstract "The exciting developments of the past year occurring since our last comprehensive review of NMDA receptor pharmacological agents as drugs [1], not yet appearing in the refereed literature, involve the use of NMDA antagonists in stroke and traumatic brain injury. A year ago, there seemed to be a three way tie in the race for effective ‘brain-attack’ (emergency anti-stroke rescue therapy) and traumatic brain injury therapy between the anti-oxidant tirilazad (Upjohn), the NMDA-antagonist selfotel (Ciba, CGS 19755), and the NMDA-antagonist eliprodil (Synthelabo/Searle/Lorex, SL 82.0715). Unexpected side-effects severely retarded the progress of tirilazad, and the ‘dark horse’ glutamate-release blocker lubeluzole (Janssen) suddenly burst into, possibly, the leading position in this race, with selfotel and eliprodil still jockeying effectively as they move into Phase III trials in stroke. Some attention has also been focused on trials involving drug combinations. Although theoretically this would offer the adva..." @default.
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- W2080206544 date "1995-05-01" @default.
- W2080206544 modified "2023-09-28" @default.
- W2080206544 title "MonthlyUpdate—Central & Peripheral Nervous Systems: Pharmacotherapeutic Potential for Compounds Acting at NMDA Receptors: Update 1995" @default.
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- W2080206544 doi "https://doi.org/10.1517/13543784.4.5.475" @default.
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