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- W2080208383 abstract "Two main hypotheses describe the role of hemoglobin in the regulation of nitric oxide (NO) bioavailability. It has been suggested that hemoglobin interacts with circulating NO, forming Fe-nitrosyl hemoglobin and then S-nitrosothiols, which deliver NO extracellularly by an allosterically regulated mechanism. Alternatively, the existence of diffusional barriers that protect NO from hemoglobin-mediated degradation has been proposed. The reliability of each model in vivo is supported by the detection of physiological hematic levels of S-nitrosohemoglobin. However, the measured concentrations of S-nitrosohemoglobin are largely divergent between the two models. Moreover, recent reports suggest that circulating levels of S-nitrosohemoglobin in human blood could be significantly lower than assessed previously. We suggest that solving the methodological controversies that make the field of NO research a ‘minefield’, even for skilled analysts, is fundamental to understanding the role of S-nitrosothiols in the vasculature." @default.
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- W2080208383 date "2004-06-01" @default.
- W2080208383 modified "2023-10-17" @default.
- W2080208383 title "Nitric oxide, S-nitrosothiols and hemoglobin: is methodology the key?" @default.
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- W2080208383 doi "https://doi.org/10.1016/j.tips.2004.04.009" @default.
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