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• W2080209053 abstract "Hypnotics are widely used by the elderly, and their impact on mortality remains controversial.The objective was to examine the association between the use of hypnotics and mortality risk in a large cohort of community-dwelling elderly, taking into account a wide range of potential competing risks including sociodemographic characteristics, lifestyle, and chronic disorders as well as underlying psychiatric disorders, excessive daytime sleepiness, and insomnia complaints. Analyses were carried out on 6696 subjects aged 65 years or older randomly recruited from three French cities and free of dementia at baseline.Adjusted Cox proportional hazards models with delayed entry, and age of the participants as the time scale, were used to determine the association between hypnotic use and 12-year survival. At baseline, 21.7% of the participants regularly used at least one hypnotic.During follow-up, 1307 persons died; 480 from cancer and 344 from cardiovascular disease.Analyses adjusted for study center, age and gender showed a significantly greater risk of all-cause and cardiovascular-related mortality with hypnotics, particularly benzodiazepines, and this increased with the number of hypnotics used.None of these associations were significant in models adjusting for socio-demographic characteristics, lifestyle, chronic disorders including cardiovascular pathologies, sleep and psychiatric disorders.Results remained unchanged when duration of past- hypnotic intake or persistent vs intermittent use during follow-up were taken into account. When controlling for a large range of potential confounders, the risk of mortality was not significantly associated with hypnotic use regardless of the type and duration.Underlying psychiatric disorders appear to be the principal confounders of the observed association. The 3C Study is conducted under a partnership agreement between Inserm, the Bordeaux II University and Sanofi- Synthélabo.The FRM funded the preparation and first phase of the study.The 3C-Study is also supported by the CNMTS, DGS, MGEN, Institut de la Longévité,AFSSPS, the Regional Governments of Aquitaine, Bourgogne and Languedoc-Roussillon and, the Fondation de France, the Ministry of Research-Inserm Programme “Cohorts and collection of biological material”. Part of this project is financed by grants from the ANR and Fondation Plan Alzheimer." @default.
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• W2080209053 date "2013-12-01" @default.
• W2080209053 modified "2023-09-26" @default.
• W2080209053 title "Hypnotics and mortality in an elderly general population: A 12-year prospective study" @default.
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• W2080209053 doi "https://doi.org/10.1016/j.sleep.2013.11.369" @default.
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