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- W2080210318 abstract "In this study, cytokine secretion capacity and maturation phenotype of human lymphoma-associated splenic macrophages (LASM) were evaluated in a long-term culture. Sixteen spleens from malignant lymphoma patients and five control spleens were investigated. Splenic macrophages (SM) were isolated by teflon adherence and cultured for 6-48 days. Secretion of IL-1α, IL-6 and TNFα was measured by ELISA following maximal stimulation with LPS and IFN-γ, and cytokine mRNA expression was detected by in situ hybridization. Immunohistochemical expression of maturationassociated antigens was evaluated semiquantitatively. Cytokine secretion capacity was significantly altered in LASM which exhibited reduced TNFa and IL-6, but elevated IL-l a secretion when compared to control SM. Alterations of cytokine secretion capacity were associated with a modification of LASM maturation phenotype, showing impaired expression of early and chronic/ late inflammatory markers. These findings obtained from a long-term culture model suggest that malignant lymphomas induce lasting modifications of cytokine secretion and maturation patterns in LASM." @default.
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- W2080210318 date "1997-01-01" @default.
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- W2080210318 title "In vitro Cytokine Secretion and Maturation Phenotype of lymphoma-Associated Splenic Macrophages" @default.
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- W2080210318 doi "https://doi.org/10.1016/s0344-0338(97)80105-7" @default.
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