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• W2080212882 abstract "Major histocompatibility complex (MHC) molecules carrying selected peptides will bind specifically to their cognate T-cell receptor on individual clones of reactive T cells. Fluorescently labeled, tetrameric MHC-peptide complexes have been widely used to detect and quantitate antigen-specific T-cell populations via flow cytometry. We hypothesized that such MHC-peptide tetramers could also be used to selectively deplete unique reactive T-cell populations, while leaving the remaining T-cell repertoire and immune response intact. In this report, we successfully demonstrate that a tetramer-based depletion of T cells can be achieved in a murine model of allogeneic bone marrow transplantation. Depletion of a specific alloreactive population of donor splenocytes (< 0.5% of CD8+ T cells) prior to transplantation significantly decreased morbidity and mortality from graft-versus-host disease. There was no early regrowth of the antigen-specific T cells in the recipient and in vivo T-cell proliferation was greatly reduced as well. Survival was increased more than 3-fold over controls, yet the inherent antitumor activity of the transplant was retained. This method also provides the proof-of-concept for similar strategies to selectively remove other unwanted T-cell clones, which could result in novel therapies for certain autoimmune disorders, T-cell malignancies, and solid organ graft rejection." @default.
• W2080212882 created "2016-06-24" @default.
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• W2080212882 date "2006-03-01" @default.
• W2080212882 modified "2023-09-27" @default.
• W2080212882 title "Remodeling specific immunity by use of MHC tetramers: demonstration in a graft-versus-host disease model" @default.
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• W2080212882 doi "https://doi.org/10.1182/blood-2005-07-2828" @default.
• W2080212882 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1895712" @default.
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