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- W2080213498 abstract "Circadian rhythm disorder is a common neurological deficit caused by neonatal hypoxic-ischemic brain damage (HIBD). However, little is known about its underlying mechanisms. Our previous studies revealed a significant elevation of clock genes at the protein, but not mRNA, levels in the pineal gland after neonatal HIBD. To investigate the mechanisms of post-transcriptional regulation on clock genes, we screened changes of miRNA levels in the pineal gland after neonatal HIBD using high-throughput arrays. Within the miRNAs whose expression was significantly down-regulated, we identified one miRNA (miR182) that targeted the 3'-untranslated region (3'-UTR) of Clock, a key component of clock genes, and played a crucial role in regulating CLOCK expression after oxygen-glucose deprivation in primarily cultured pinealocytes. Our findings therefore provide new insight on studies of therapeutic targets for circadian rhythm disturbance after neonatal HIBD." @default.
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- W2080213498 date "2015-03-01" @default.
- W2080213498 modified "2023-10-16" @default.
- W2080213498 title "The role of miR-182 in regulating pineal CLOCK expression after hypoxia-ischemia brain injury in neonatal rats" @default.
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- W2080213498 doi "https://doi.org/10.1016/j.neulet.2015.02.026" @default.
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