Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080218311> ?p ?o ?g. }
- W2080218311 endingPage "1020" @default.
- W2080218311 startingPage "1009" @default.
- W2080218311 abstract "Transcriptional regulation plays a critical role in the life cycle of Mycobacterium smegmatis and its related species, M. tuberculosis, the causative microbe for tuberculosis. However, the key transcriptional factors involved in broad regulation of diverse genes remain to be characterized in mycobacteria. In the present study, a TetR-like family transcriptional factor, Ms6564, was characterized in M. smegmatis as a master regulator. A conserved 19 bp-palindromic motif was identified for Ms6564 binding using DNaseI footprinting and EMSA. A total of 339 potential target genes for Ms6564 were further characterized by searching the M. smegmatis genome based on the sequence motif. Notably, Ms6564 bound with the promoters of 37 cell cycle and DNA damage/repair genes and regulated positively their expressions. The Ms6564-overexpressed recombinant strain yielded 5-fold lower mutation rates and mutation frequencies, whereas deletion of Ms6564 resulted in ∼5-fold higher mutation rates for the mutant strain compared with the wild-type strain. These findings suggested that Ms6564 may function as a global regulator and might be a sensor necessary for activation of DNA damage/repair genes." @default.
- W2080218311 created "2016-06-24" @default.
- W2080218311 creator A5006076609 @default.
- W2080218311 creator A5008950262 @default.
- W2080218311 creator A5023179600 @default.
- W2080218311 creator A5072098243 @default.
- W2080218311 creator A5087945816 @default.
- W2080218311 date "2011-10-05" @default.
- W2080218311 modified "2023-09-23" @default.
- W2080218311 title "A TetR-like regulator broadly affects the expressions of diverse genes in Mycobacterium smegmatis" @default.
- W2080218311 cites W1490937614 @default.
- W2080218311 cites W1579020917 @default.
- W2080218311 cites W1677285916 @default.
- W2080218311 cites W1816644759 @default.
- W2080218311 cites W1892799384 @default.
- W2080218311 cites W1967457339 @default.
- W2080218311 cites W1981198757 @default.
- W2080218311 cites W1993063963 @default.
- W2080218311 cites W2001947730 @default.
- W2080218311 cites W2003103534 @default.
- W2080218311 cites W2006611385 @default.
- W2080218311 cites W2006614927 @default.
- W2080218311 cites W2013735712 @default.
- W2080218311 cites W2022472102 @default.
- W2080218311 cites W2031753305 @default.
- W2080218311 cites W2034254026 @default.
- W2080218311 cites W2041189606 @default.
- W2080218311 cites W2069511958 @default.
- W2080218311 cites W2078290231 @default.
- W2080218311 cites W2091300474 @default.
- W2080218311 cites W2105028864 @default.
- W2080218311 cites W2107277218 @default.
- W2080218311 cites W2107861779 @default.
- W2080218311 cites W2121823715 @default.
- W2080218311 cites W2126282766 @default.
- W2080218311 cites W2129634213 @default.
- W2080218311 cites W2140286346 @default.
- W2080218311 cites W2143403799 @default.
- W2080218311 cites W2144691110 @default.
- W2080218311 cites W2145111771 @default.
- W2080218311 cites W2158023121 @default.
- W2080218311 cites W2158266834 @default.
- W2080218311 cites W2161353001 @default.
- W2080218311 cites W2171535756 @default.
- W2080218311 cites W335065817 @default.
- W2080218311 doi "https://doi.org/10.1093/nar/gkr830" @default.
- W2080218311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3273814" @default.
- W2080218311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21976733" @default.
- W2080218311 hasPublicationYear "2011" @default.
- W2080218311 type Work @default.
- W2080218311 sameAs 2080218311 @default.
- W2080218311 citedByCount "52" @default.
- W2080218311 countsByYear W20802183112012 @default.
- W2080218311 countsByYear W20802183112013 @default.
- W2080218311 countsByYear W20802183112014 @default.
- W2080218311 countsByYear W20802183112015 @default.
- W2080218311 countsByYear W20802183112016 @default.
- W2080218311 countsByYear W20802183112017 @default.
- W2080218311 countsByYear W20802183112018 @default.
- W2080218311 countsByYear W20802183112019 @default.
- W2080218311 countsByYear W20802183112020 @default.
- W2080218311 countsByYear W20802183112021 @default.
- W2080218311 countsByYear W20802183112022 @default.
- W2080218311 countsByYear W20802183112023 @default.
- W2080218311 crossrefType "journal-article" @default.
- W2080218311 hasAuthorship W2080218311A5006076609 @default.
- W2080218311 hasAuthorship W2080218311A5008950262 @default.
- W2080218311 hasAuthorship W2080218311A5023179600 @default.
- W2080218311 hasAuthorship W2080218311A5072098243 @default.
- W2080218311 hasAuthorship W2080218311A5087945816 @default.
- W2080218311 hasBestOaLocation W20802183111 @default.
- W2080218311 hasConcept C101762097 @default.
- W2080218311 hasConcept C104317684 @default.
- W2080218311 hasConcept C142724271 @default.
- W2080218311 hasConcept C143065580 @default.
- W2080218311 hasConcept C150194340 @default.
- W2080218311 hasConcept C158448853 @default.
- W2080218311 hasConcept C165864922 @default.
- W2080218311 hasConcept C21592294 @default.
- W2080218311 hasConcept C22427896 @default.
- W2080218311 hasConcept C22744801 @default.
- W2080218311 hasConcept C27153228 @default.
- W2080218311 hasConcept C2777204207 @default.
- W2080218311 hasConcept C2777274385 @default.
- W2080218311 hasConcept C2777975735 @default.
- W2080218311 hasConcept C2781069245 @default.
- W2080218311 hasConcept C33498276 @default.
- W2080218311 hasConcept C54355233 @default.
- W2080218311 hasConcept C552990157 @default.
- W2080218311 hasConcept C6929976 @default.
- W2080218311 hasConcept C71924100 @default.
- W2080218311 hasConcept C86339819 @default.
- W2080218311 hasConcept C86803240 @default.
- W2080218311 hasConceptScore W2080218311C101762097 @default.
- W2080218311 hasConceptScore W2080218311C104317684 @default.
- W2080218311 hasConceptScore W2080218311C142724271 @default.
- W2080218311 hasConceptScore W2080218311C143065580 @default.
- W2080218311 hasConceptScore W2080218311C150194340 @default.