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- W2080219092 abstract "Pancreatic beta cells secrete insulin when blood glucose levels are high. Dysfunction of this glucose-stimulated insulin secretion (GSIS) is partly responsible for the manifestation of type 2 diabetes, a metabolic disorder that is rapidly becoming a global pandemic. Mitochondria play a central role in GSIS by coupling glucose oxidation to production of ATP, a signal that triggers a series of events that ultimately leads to insulin release. Beta cells express a mitochondrial uncoupling protein, UCP2, which is rather surprising as activity of such a protein is anticipated to lower the efficiency of oxidative phosphorylation, and hence to impair GSIS. The mounting evidence demonstrating that insulin secretion is indeed blunted by UCP2 agrees with this prediction, and has provoked the idea that UCP2 activity contributes to beta cell pathogenesis and development of type 2 diabetes. Although this notion may be correct, the evolved function of UCP2 remains unclear. With this paper we aim to provide a brief account of the present state of affairs in this field, suggest a physiological role for UCP2, and highlight some of our own recent results." @default.
- W2080219092 created "2016-06-24" @default.
- W2080219092 creator A5022372528 @default.
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- W2080219092 date "2008-07-01" @default.
- W2080219092 modified "2023-09-23" @default.
- W2080219092 title "On the role of uncoupling protein-2 in pancreatic beta cells" @default.
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- W2080219092 cites W1967756381 @default.
- W2080219092 cites W1970829588 @default.
- W2080219092 cites W1971701221 @default.
- W2080219092 cites W1974867660 @default.
- W2080219092 cites W1975515886 @default.
- W2080219092 cites W1979504679 @default.
- W2080219092 cites W1979856729 @default.
- W2080219092 cites W1986399270 @default.
- W2080219092 cites W1987639430 @default.
- W2080219092 cites W1991238715 @default.
- W2080219092 cites W1992678387 @default.
- W2080219092 cites W1996324277 @default.
- W2080219092 cites W2003023496 @default.
- W2080219092 cites W2005398956 @default.
- W2080219092 cites W2006226554 @default.
- W2080219092 cites W2010290591 @default.
- W2080219092 cites W2012099220 @default.
- W2080219092 cites W2016683746 @default.
- W2080219092 cites W2017280433 @default.
- W2080219092 cites W2019133751 @default.
- W2080219092 cites W2020410746 @default.
- W2080219092 cites W2028086207 @default.
- W2080219092 cites W2033573667 @default.
- W2080219092 cites W2035748369 @default.
- W2080219092 cites W2036573181 @default.
- W2080219092 cites W2038619251 @default.
- W2080219092 cites W2038977244 @default.
- W2080219092 cites W2039978417 @default.
- W2080219092 cites W2049284715 @default.
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- W2080219092 doi "https://doi.org/10.1016/j.bbabio.2008.03.022" @default.
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