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- W2080222087 abstract "Both heme and tin-protoporphyrin (TP), but not zincprotoporphyrin (ZP), supported significant NADPH-stimulated, concentration-dependent CO production in all tissues. These rates, for 400 μM substrate, ranged: for heme 0.52 (intestine) to 4.18 (spleen); for TP 0.08 (kidney) to 0.71 (liver); and for ZP 0.01 (liver) to 0.25 (kidney) nmoles CO/hr/mg protein. All three metalloporphyrins (400 μM) supported concentration-dependent CO production in the absence of NADPH. The rates ranged: for heme 0.31 (kidney) to 0.80 (spleen); for TP 0.41 (kidney) to 1.04 (intestine); and for ZP 0.12 (kidney) to 0.51 (spleen) nmoles/hr/mg protein. We conclude that both TP and ZP are subject to in vitro degradation by 13,000 × g supernatants of adult rat organs via CO-producing reactions." @default.
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- W2080222087 date "1987-10-01" @default.
- W2080222087 modified "2023-09-27" @default.
- W2080222087 title "Carbon monoxide generation from tin- and zinc-protoporphyrin by tissue homogenates" @default.
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- W2080222087 doi "https://doi.org/10.1016/0006-291x(87)91127-2" @default.
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