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- W2080222154 abstract "An aerosol bolus technique was used to estimate where inspired particles deposit in the human respiratory tract. Aerosol boli were introduced at preselected points during an inspiration of 1 litre of air and thus penetrated to different depths in the lungs. Di-2-ethylhexyl sebacate droplets of 1 μm diameter served as aerosol particles. Particle losses in the respiratory tract were calculated from recorded instantaneous particle number concentration and respired volume. The deeper a bolus penetrated into the lungs the larger was dispersion and the larger was the fraction of inspired particles which deposited. Dispersion and deposition could be described by a matrix formalism which revealed that dispersion can be neglected for the estimation of deposition when the entire tidal air contains particles. That portion of the respiratory tract ventilated by a tidal volume of 1 litre was then considered as a series of 10 particle collecting regions. The collection efficiency of a region was found to be larger the deeper the region was located in the lungs. However, particle deposition from a single tidal inspiration of an aerosol increased in the first 4 regions and decreased in the last 4 regions. These data are comparable to data that were computed from mathematical deposition models and may be used to evaluate their accuracy." @default.
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- W2080222154 date "1988-01-01" @default.
- W2080222154 modified "2023-09-26" @default.
- W2080222154 title "Particle Deposition in Volumetric Regions of the Human Respiratory Tract" @default.
- W2080222154 cites W2006470301 @default.
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- W2080222154 doi "https://doi.org/10.1093/annhyg/32.inhaled_particles_vi.71" @default.
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