FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080223889> ?p ?o ?g. }

• W2080223889 endingPage "1291" @default.
• W2080223889 startingPage "1283" @default.
• W2080223889 abstract "The present study investigated the effect of dietary zinc deficiency during the developmental period on hepatic cytochrome P450 (CYP) expression in postpubertal male rats. Twenty-one-day-old weanling male Wistar rats were randomly assigned to one of the following dietary groups: zinc-adequate (31 mg zinc/kg diet); marginal zinc-deficient (3 mg zinc/kg diet); severe zinc-deficient (1 mg zinc/kg diet); or pair-fed control for either the marginal or severe zinc-deficient group. All rats were killed at 63 days of age. Compared with the corresponding pair-fed controls, marginal zinc deficiency decreased CYP2C11-mediated testosterone 2alpha- and 16alpha-hydroxylase activities by 43 and 42%, respectively, whereas severe zinc deficiency reduced each of these activities by approximately 60%. The decrease in CYP2C11 activity was accompanied by a reduction in CYP2C11 protein and mRNA levels, as assessed by immunoblot and reverse transcription-polymerase chain reaction (RT-PCR) assays, respectively. Additional RT-PCR analysis indicated that severe zinc deficiency decreased CYP3A2 and CYP3A18 mRNA levels by 49 and 43%, respectively, whereas it increased CYP2C12 (253%) and CYP3A9 (238%) mRNA expression. Plasma testosterone concentration was decreased by 67% in the marginal zinc-deficient group when compared with the corresponding pair-fed control group. By comparison, it was below the limit of quantification (0.2 ng/mL) in the severe zinc-deficient rats. Overall, these results indicate that dietary zinc deficiency during the developmental period feminized the hepatic gene expression of the sexually dimorphic CYP2C11, CYP3A2, CYP3A18, CYP2C12, and CYP3A9 in postpubertal male rats." @default.
• W2080223889 created "2016-06-24" @default.
• W2080223889 creator A5010972428 @default.
• W2080223889 creator A5037041945 @default.
• W2080223889 creator A5043664040 @default.
• W2080223889 creator A5064443673 @default.
• W2080223889 date "2001-11-01" @default.
• W2080223889 modified "2023-10-10" @default.
• W2080223889 title "Influence of dietary zinc deficiency during development on hepatic CYP2C11, CYP2C12, CYP3A2, CYP3A9, and CYP3A18 expression in postpubertal male rats11Abbreviations: CYP, cytochrome P450; GH, growth hormone; and RT-PCR, reverse transcription-polymerase chain reaction." @default.
• W2080223889 cites W1492298052 @default.
• W2080223889 cites W1498899003 @default.
• W2080223889 cites W1532212858 @default.
• W2080223889 cites W1590889826 @default.
• W2080223889 cites W1604915447 @default.
• W2080223889 cites W1866176581 @default.
• W2080223889 cites W1973117081 @default.
• W2080223889 cites W1981223158 @default.
• W2080223889 cites W1981435376 @default.
• W2080223889 cites W1983398711 @default.
• W2080223889 cites W1983999968 @default.
• W2080223889 cites W1992997858 @default.
• W2080223889 cites W1996004317 @default.
• W2080223889 cites W1999858228 @default.
• W2080223889 cites W2000964834 @default.
• W2080223889 cites W2014898229 @default.
• W2080223889 cites W2021022873 @default.
• W2080223889 cites W2028627761 @default.
• W2080223889 cites W2039422123 @default.
• W2080223889 cites W2044046302 @default.
• W2080223889 cites W2053325489 @default.
• W2080223889 cites W2053327575 @default.
• W2080223889 cites W2057187148 @default.
• W2080223889 cites W2063362414 @default.
• W2080223889 cites W2072370222 @default.
• W2080223889 cites W2075497267 @default.
• W2080223889 cites W2084973323 @default.
• W2080223889 cites W2091124986 @default.
• W2080223889 cites W2093918159 @default.
• W2080223889 cites W2094230228 @default.
• W2080223889 cites W2099189659 @default.
• W2080223889 cites W2133707687 @default.
• W2080223889 cites W2148241831 @default.
• W2080223889 cites W2163356356 @default.
• W2080223889 doi "https://doi.org/10.1016/s0006-2952(01)00776-6" @default.
• W2080223889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11705462" @default.
• W2080223889 hasPublicationYear "2001" @default.
• W2080223889 type Work @default.
• W2080223889 sameAs 2080223889 @default.
• W2080223889 citedByCount "13" @default.
• W2080223889 countsByYear W20802238892013 @default.
• W2080223889 countsByYear W20802238892015 @default.
• W2080223889 countsByYear W20802238892016 @default.
• W2080223889 countsByYear W20802238892018 @default.
• W2080223889 crossrefType "journal-article" @default.
• W2080223889 hasAuthorship W2080223889A5010972428 @default.
• W2080223889 hasAuthorship W2080223889A5037041945 @default.
• W2080223889 hasAuthorship W2080223889A5043664040 @default.
• W2080223889 hasAuthorship W2080223889A5064443673 @default.
• W2080223889 hasConcept C104317684 @default.
• W2080223889 hasConcept C126322002 @default.
• W2080223889 hasConcept C134018914 @default.
• W2080223889 hasConcept C150194340 @default.
• W2080223889 hasConcept C178790620 @default.
• W2080223889 hasConcept C185592680 @default.
• W2080223889 hasConcept C2776928490 @default.
• W2080223889 hasConcept C2778433245 @default.
• W2080223889 hasConcept C2779279991 @default.
• W2080223889 hasConcept C526171541 @default.
• W2080223889 hasConcept C535196362 @default.
• W2080223889 hasConcept C55493867 @default.
• W2080223889 hasConcept C62231903 @default.
• W2080223889 hasConcept C71924100 @default.
• W2080223889 hasConcept C86803240 @default.
• W2080223889 hasConceptScore W2080223889C104317684 @default.
• W2080223889 hasConceptScore W2080223889C126322002 @default.
• W2080223889 hasConceptScore W2080223889C134018914 @default.
• W2080223889 hasConceptScore W2080223889C150194340 @default.
• W2080223889 hasConceptScore W2080223889C178790620 @default.
• W2080223889 hasConceptScore W2080223889C185592680 @default.
• W2080223889 hasConceptScore W2080223889C2776928490 @default.
• W2080223889 hasConceptScore W2080223889C2778433245 @default.
• W2080223889 hasConceptScore W2080223889C2779279991 @default.
• W2080223889 hasConceptScore W2080223889C526171541 @default.
• W2080223889 hasConceptScore W2080223889C535196362 @default.
• W2080223889 hasConceptScore W2080223889C55493867 @default.
• W2080223889 hasConceptScore W2080223889C62231903 @default.
• W2080223889 hasConceptScore W2080223889C71924100 @default.
• W2080223889 hasConceptScore W2080223889C86803240 @default.
• W2080223889 hasIssue "9" @default.
• W2080223889 hasLocation W20802238891 @default.
• W2080223889 hasLocation W20802238892 @default.
• W2080223889 hasOpenAccess W2080223889 @default.
• W2080223889 hasPrimaryLocation W20802238891 @default.
• W2080223889 hasRelatedWork W1508957066 @default.
• W2080223889 hasRelatedWork W163455541 @default.
• W2080223889 hasRelatedWork W1741672376 @default.
• W2080223889 hasRelatedWork W1999615337 @default.
• W2080223889 hasRelatedWork W2045677033 @default.

• next