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• W2080227772 abstract "Bovine milk is known to exert a potent chemotactic activity on neutrophils, but the responsible agent has not been identified. The objective of the study was to characterize the main biochemical component responsible for this chemotactic activity. A neutrophil shape change assay was used to locate active milk fractions separated by chromatography. A single protein was isolated and identified by amino acid sequencing and mass spectrometry as CXCL3. Recombinant bovine chemokines and specific antibodies were used to show that normal milk contains active concentrations of CXCL1 (1–5 ng/ml) and CXCL3 (100–500 ng/ml), whereas CXCL2 and CXCL8/IL-8 were not detected. Depletion experiments with antibodies showed that CXCL3 was the main chemotaxin for neutrophils in normal (non-mastitic) milk. The chemokine CXCL3 was located by immunohistochemistry in mammary epithelial cells, and abundant mRNA was found in uninflamed mammary tissue, suggesting constitutive secretion by the lactating mammary epithelium. These results indicate that CXCL3/GRO-γ is the major chemotactic factor for neutrophils in bovine milk in the absence of inflammation, and that it is secreted constitutively in milk by mammary epithelial cells. This finding prompts the question of the biological significance of permanent high concentrations of a CXC chemokine in milk." @default.
• W2080227772 created "2016-06-24" @default.
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• W2080227772 date "2008-09-01" @default.
• W2080227772 modified "2023-10-17" @default.
• W2080227772 title "The chemokine CXCL3 is responsible for the constitutive chemotactic activity of bovine milk for neutrophils" @default.
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• W2080227772 doi "https://doi.org/10.1016/j.molimm.2008.06.010" @default.
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