FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080231508> ?p ?o ?g. }

• W2080231508 endingPage "1814" @default.
• W2080231508 startingPage "1809" @default.
• W2080231508 abstract "Venoms consist of a complex mixture of toxic components that are used by a variety of animal species for defense and predation. Envenomation of mammalian species leads to an acute inflammatory response and can lead to the development of IgE-dependent venom allergy. However, the mechanisms by which the innate immune system detects envenomation and initiates inflammatory and allergic responses to venoms remain largely unknown. Here we show that bee venom is detected by the NOD-like receptor family, pyrin domain-containing 3 inflammasome and can trigger activation of caspase-1 and the subsequent processing and unconventional secretion of the leaderless proinflammatory cytokine IL-1β in macrophages. Whereas activation of the inflammasome by bee venom induces a caspase-1–dependent inflammatory response, characterized by recruitment of neutrophils to the site or envenomation, the inflammasome is dispensable for the allergic response to bee venom. Finally, we find that caspase-1–deficient mice are more susceptible to the noxious effects of bee and snake venoms, suggesting that a caspase-1–dependent immune response can protect against the damaging effects of envenomation." @default.
• W2080231508 created "2016-06-24" @default.
• W2080231508 creator A5022058492 @default.
• W2080231508 creator A5040597705 @default.
• W2080231508 date "2013-01-07" @default.
• W2080231508 modified "2023-10-12" @default.
• W2080231508 title "Role of the inflammasome in defense against venoms" @default.
• W2080231508 cites W1965898267 @default.
• W2080231508 cites W1977405115 @default.
• W2080231508 cites W1977846299 @default.
• W2080231508 cites W1992789370 @default.
• W2080231508 cites W1998100138 @default.
• W2080231508 cites W2008581589 @default.
• W2080231508 cites W2009800174 @default.
• W2080231508 cites W2012907151 @default.
• W2080231508 cites W2027351323 @default.
• W2080231508 cites W2033851989 @default.
• W2080231508 cites W2034708867 @default.
• W2080231508 cites W2034846626 @default.
• W2080231508 cites W2040230067 @default.
• W2080231508 cites W2048189287 @default.
• W2080231508 cites W2050449334 @default.
• W2080231508 cites W2055408817 @default.
• W2080231508 cites W2065375178 @default.
• W2080231508 cites W2078169364 @default.
• W2080231508 cites W2079843658 @default.
• W2080231508 cites W2080827095 @default.
• W2080231508 cites W2081343476 @default.
• W2080231508 cites W2100969613 @default.
• W2080231508 cites W2103358704 @default.
• W2080231508 cites W2106449364 @default.
• W2080231508 cites W2107153285 @default.
• W2080231508 cites W2110659602 @default.
• W2080231508 cites W2113906902 @default.
• W2080231508 cites W2122855969 @default.
• W2080231508 cites W2127130381 @default.
• W2080231508 cites W2159421887 @default.
• W2080231508 cites W2187608003 @default.
• W2080231508 cites W4211217520 @default.
• W2080231508 cites W4256036026 @default.
• W2080231508 doi "https://doi.org/10.1073/pnas.1221476110" @default.
• W2080231508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3562764" @default.
• W2080231508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23297192" @default.
• W2080231508 hasPublicationYear "2013" @default.
• W2080231508 type Work @default.
• W2080231508 sameAs 2080231508 @default.
• W2080231508 citedByCount "44" @default.
• W2080231508 countsByYear W20802315082013 @default.
• W2080231508 countsByYear W20802315082014 @default.
• W2080231508 countsByYear W20802315082015 @default.
• W2080231508 countsByYear W20802315082016 @default.
• W2080231508 countsByYear W20802315082017 @default.
• W2080231508 countsByYear W20802315082019 @default.
• W2080231508 countsByYear W20802315082020 @default.
• W2080231508 countsByYear W20802315082021 @default.
• W2080231508 countsByYear W20802315082022 @default.
• W2080231508 countsByYear W20802315082023 @default.
• W2080231508 crossrefType "journal-article" @default.
• W2080231508 hasAuthorship W2080231508A5022058492 @default.
• W2080231508 hasAuthorship W2080231508A5040597705 @default.
• W2080231508 hasBestOaLocation W20802315081 @default.
• W2080231508 hasConcept C136449434 @default.
• W2080231508 hasConcept C139174496 @default.
• W2080231508 hasConcept C139964883 @default.
• W2080231508 hasConcept C145600735 @default.
• W2080231508 hasConcept C164027704 @default.
• W2080231508 hasConcept C203014093 @default.
• W2080231508 hasConcept C2776914184 @default.
• W2080231508 hasConcept C2777209026 @default.
• W2080231508 hasConcept C2779448229 @default.
• W2080231508 hasConcept C55493867 @default.
• W2080231508 hasConcept C86803240 @default.
• W2080231508 hasConcept C8891405 @default.
• W2080231508 hasConceptScore W2080231508C136449434 @default.
• W2080231508 hasConceptScore W2080231508C139174496 @default.
• W2080231508 hasConceptScore W2080231508C139964883 @default.
• W2080231508 hasConceptScore W2080231508C145600735 @default.
• W2080231508 hasConceptScore W2080231508C164027704 @default.
• W2080231508 hasConceptScore W2080231508C203014093 @default.
• W2080231508 hasConceptScore W2080231508C2776914184 @default.
• W2080231508 hasConceptScore W2080231508C2777209026 @default.
• W2080231508 hasConceptScore W2080231508C2779448229 @default.
• W2080231508 hasConceptScore W2080231508C55493867 @default.
• W2080231508 hasConceptScore W2080231508C86803240 @default.
• W2080231508 hasConceptScore W2080231508C8891405 @default.
• W2080231508 hasIssue "5" @default.
• W2080231508 hasLocation W20802315081 @default.
• W2080231508 hasLocation W20802315082 @default.
• W2080231508 hasLocation W20802315083 @default.
• W2080231508 hasLocation W20802315084 @default.
• W2080231508 hasOpenAccess W2080231508 @default.
• W2080231508 hasPrimaryLocation W20802315081 @default.
• W2080231508 hasRelatedWork W1813528403 @default.
• W2080231508 hasRelatedWork W2047423808 @default.
• W2080231508 hasRelatedWork W2080231508 @default.
• W2080231508 hasRelatedWork W2096259698 @default.
• W2080231508 hasRelatedWork W2130940574 @default.
• W2080231508 hasRelatedWork W2382886602 @default.

• next