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- W2080232635 abstract "The orvinols are a class of potent opioids which have been extensively studied, yet little is known about the effects of introducing substituents into the 18- and 19-positions. The etheno bridge of thevinone was hydroxylated to give both the 18- and 19-hydroxyl substituted thevinols. After 3-O-demethylation to the corresponding orvinols, binding and GTPγS functional assays indicated that hydroxyl substitution at the 18- and 19-positions differentially affects the μ opioid efficacy of orvinols." @default.
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- W2080232635 date "2007-09-01" @default.
- W2080232635 modified "2023-09-27" @default.
- W2080232635 title "Functionalization of the 6,14-bridge of the orvinols. Part 3: Preparation and pharmacological evaluation of 18- and 19-hydroxyl substituted orvinols" @default.
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- W2080232635 doi "https://doi.org/10.1016/j.bmcl.2007.06.050" @default.
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