FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080233875> ?p ?o ?g. }

• W2080233875 endingPage "35" @default.
• W2080233875 startingPage "2929" @default.
• W2080233875 abstract "Three monoclonal antibodies which strongly bind to Hodgkin and Reed-Sternberg cells and two corresponding Fab' fragments were linked to deglycosylated ricin A chain (dg A) to evaluate their potential as immunotoxins for the treatment of Hodgkin's disease. Two of the antibodies, Ber-H2 and HRS-3, were shown to bind to the same epitope on the CD30 antigen, whereas the third antibody, IRac, bound to a different antigen. None of the antibodies significantly cross-reacted with normal human tissues as judged by indirect immunofluorescence and immunoperoxidase analyses on frozen sections from 28 normal tissues. All three antibodies formed potent and specific immunotoxins. They inhibited protein synthesis of the L540 Hodgkin's disease cell line in vitro by 50% at concentrations of 1 x 10(-11) M for IRac.dgA, 9 x 10(-11) M for HRS-3.dgA, and 2 x 10(-10) M for Ber-H2.dgA. HRS-3 Fab' and IRac Fab' immunotoxins were 7.8- and 60-fold less cytotoxic, respectively, than their intact counterparts in vitro. In vivo, a single i.v. injection of a dose of Ber-H2.dgA, HRS-3.dgA, or IRac.dgA corresponding to 40% of the LD50 induced lasting complete remissions in 38, 44, and 50%, respectively, of mice with solid s.c. L540 tumors of 60 to 80 mm3 size (0.5-cm diameter). At equivalent dosage (40% of the LD50), the HRS-3 Fab'.dgA and the IRac Fab'.dgA both induced lasting complete remissions in 25% of the mice, although the HRS-3 Fab'.dgA was significantly superior to IRac Fab'.dgA at retarding tumor growth in the remaining animals. The effectiveness of the immunotoxins depended on the size of the tumor at the time of injection, since IRac.dgA treatment induced complete remissions in 100% of mice with small tumors (10 to 20 mm3, approximately 0.3 cm in diameter) but only 13% of mice with larger tumors of 400 to 600 mm3 (approximately 1 cm in diameter). Tumors which regrew after IRac.dgA treatment mainly consisted of antigen-deficient mutants having reduced sensitivity to IRac.dgA but normal sensitivity to HRS-3.dgA. It is concluded that HRS-3.dgA, HRS-3 Fab'.dgA, and IRac.dgA are candidates for the treatment of Hodgkin's disease in humans." @default.
• W2080233875 created "2016-06-24" @default.
• W2080233875 creator A5003056562 @default.
• W2080233875 creator A5004153682 @default.
• W2080233875 creator A5014979722 @default.
• W2080233875 creator A5035275962 @default.
• W2080233875 creator A5057387418 @default.
• W2080233875 creator A5067894019 @default.
• W2080233875 creator A5081603866 @default.
• W2080233875 date "1990-05-15" @default.
• W2080233875 modified "2023-10-16" @default.
• W2080233875 title "Antitumor effects of ricin A chain immunotoxins prepared from intact antibodies and Fab' fragments on solid human Hodgkin's disease tumors in mice." @default.
• W2080233875 cites W1487067064 @default.
• W2080233875 cites W1500329803 @default.
• W2080233875 cites W1521074246 @default.
• W2080233875 cites W1541287496 @default.
• W2080233875 cites W1584383434 @default.
• W2080233875 cites W1840837207 @default.
• W2080233875 cites W1941328144 @default.
• W2080233875 cites W1973835842 @default.
• W2080233875 cites W2029386719 @default.
• W2080233875 cites W2064109899 @default.
• W2080233875 cites W2066801721 @default.
• W2080233875 cites W2071263686 @default.
• W2080233875 cites W2118395503 @default.
• W2080233875 cites W2124829257 @default.
• W2080233875 cites W2132437826 @default.
• W2080233875 cites W2137011159 @default.
• W2080233875 cites W2140308459 @default.
• W2080233875 cites W2166129740 @default.
• W2080233875 cites W2171699424 @default.
• W2080233875 cites W2269861991 @default.
• W2080233875 cites W2282729572 @default.
• W2080233875 cites W2409260685 @default.
• W2080233875 cites W1838376532 @default.
• W2080233875 cites W2151477771 @default.
• W2080233875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1692251" @default.
• W2080233875 hasPublicationYear "1990" @default.
• W2080233875 type Work @default.
• W2080233875 sameAs 2080233875 @default.
• W2080233875 citedByCount "31" @default.
• W2080233875 countsByYear W20802338752012 @default.
• W2080233875 countsByYear W20802338752013 @default.
• W2080233875 countsByYear W20802338752014 @default.
• W2080233875 countsByYear W20802338752017 @default.
• W2080233875 countsByYear W20802338752018 @default.
• W2080233875 countsByYear W20802338752019 @default.
• W2080233875 crossrefType "journal-article" @default.
• W2080233875 hasAuthorship W2080233875A5003056562 @default.
• W2080233875 hasAuthorship W2080233875A5004153682 @default.
• W2080233875 hasAuthorship W2080233875A5014979722 @default.
• W2080233875 hasAuthorship W2080233875A5035275962 @default.
• W2080233875 hasAuthorship W2080233875A5057387418 @default.
• W2080233875 hasAuthorship W2080233875A5067894019 @default.
• W2080233875 hasAuthorship W2080233875A5081603866 @default.
• W2080233875 hasConcept C115085202 @default.
• W2080233875 hasConcept C147483822 @default.
• W2080233875 hasConcept C150903083 @default.
• W2080233875 hasConcept C153911025 @default.
• W2080233875 hasConcept C159654299 @default.
• W2080233875 hasConcept C185592680 @default.
• W2080233875 hasConcept C195616568 @default.
• W2080233875 hasConcept C202751555 @default.
• W2080233875 hasConcept C203014093 @default.
• W2080233875 hasConcept C207001950 @default.
• W2080233875 hasConcept C2777200438 @default.
• W2080233875 hasConcept C2777367657 @default.
• W2080233875 hasConcept C542903549 @default.
• W2080233875 hasConcept C55493867 @default.
• W2080233875 hasConcept C71924100 @default.
• W2080233875 hasConcept C86803240 @default.
• W2080233875 hasConcept C98274493 @default.
• W2080233875 hasConceptScore W2080233875C115085202 @default.
• W2080233875 hasConceptScore W2080233875C147483822 @default.
• W2080233875 hasConceptScore W2080233875C150903083 @default.
• W2080233875 hasConceptScore W2080233875C153911025 @default.
• W2080233875 hasConceptScore W2080233875C159654299 @default.
• W2080233875 hasConceptScore W2080233875C185592680 @default.
• W2080233875 hasConceptScore W2080233875C195616568 @default.
• W2080233875 hasConceptScore W2080233875C202751555 @default.
• W2080233875 hasConceptScore W2080233875C203014093 @default.
• W2080233875 hasConceptScore W2080233875C207001950 @default.
• W2080233875 hasConceptScore W2080233875C2777200438 @default.
• W2080233875 hasConceptScore W2080233875C2777367657 @default.
• W2080233875 hasConceptScore W2080233875C542903549 @default.
• W2080233875 hasConceptScore W2080233875C55493867 @default.
• W2080233875 hasConceptScore W2080233875C71924100 @default.
• W2080233875 hasConceptScore W2080233875C86803240 @default.
• W2080233875 hasConceptScore W2080233875C98274493 @default.
• W2080233875 hasIssue "10" @default.
• W2080233875 hasLocation W20802338751 @default.
• W2080233875 hasOpenAccess W2080233875 @default.
• W2080233875 hasPrimaryLocation W20802338751 @default.
• W2080233875 hasRelatedWork W1604248381 @default.
• W2080233875 hasRelatedWork W1987801792 @default.
• W2080233875 hasRelatedWork W1999614011 @default.
• W2080233875 hasRelatedWork W2000578943 @default.
• W2080233875 hasRelatedWork W2049463037 @default.

• next