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- W2080234866 abstract "This work studies the antinociceptive effect of a sustained (7 day) release dosage form of vapreotide, a peptidic analogue of somatostatin, in rats submitted to a nociceptive mechanical stimulus (paw pressure). One intramuscular injection (0.6 mg/animal) induced a significant antinociceptive effect for 7 complete days with a maximal increase in vocalization thresholds of 68 +/- 5% and a plateau of activity during the first 4 days. This action was totally inhibited by naloxone (1 mg kg-1, s.c.) injected 24 h or 6 days after vapreotide, suggesting an opioidergic involvement throughout the antinociceptive effect. These findings suggest potential interest in human therapy." @default.
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- W2080234866 date "1994-01-01" @default.
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- W2080234866 title "Seven-day antinociceptive effect of a sustained release vapreotide formulation" @default.
- W2080234866 doi "https://doi.org/10.1097/00001756-199401000-00028" @default.
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