Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080237580> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2080237580 endingPage "386" @default.
- W2080237580 startingPage "381" @default.
- W2080237580 abstract "To clarify the hemodynamic effects of the newly introduced analgesic, pentazocine, 30 dogs were studied with a right heart bypass preparation using an isovolumetric balloon technique. Heart rate and coronary artery perfusion pressure were held constant. After the rapid intravenous administration of 2.5 mg. per kilogram of pentazocine the left ventricular pressure (LVP) increased by 28 per cent, LV dpdt max. increased by 46 per cent, and the forcevelocity curve was shifted upward and to the right indicating a positive inotropic effect. The increase in contractility was noted 5 to 10 minutes after pentazocine injection and was sustained for 45 to 60 minutes. This reaction was blocked by the prior administration of propranolol, but was unaffected by previous catecholamine depletion with reserpine. All animals exhibited a transient fall in peripheral vascular resistance of 42.5 per cent within 2 minutes after pentazocine administration, but resistance returned to baseline levels within 3 minutes. Coronary blood flow and myocardial oxygen consumption were unaltered. These data indicate that pentazocine has a beta-stimulating inotropic effect, and, therefore, it may be particularly useful for providing analgesia in patients with impaired myocardial contractility. The usefulness of the drug in such patients must, however, be assessed in appropriate clinical studies." @default.
- W2080237580 created "2016-06-24" @default.
- W2080237580 creator A5001793390 @default.
- W2080237580 creator A5029815474 @default.
- W2080237580 creator A5029898727 @default.
- W2080237580 creator A5046006363 @default.
- W2080237580 date "1971-03-01" @default.
- W2080237580 modified "2023-09-27" @default.
- W2080237580 title "Experimental evaluation of pentazocine: Effect on myocardial contractility and peripheral vascular resistance" @default.
- W2080237580 cites W1508259284 @default.
- W2080237580 cites W1982070994 @default.
- W2080237580 cites W1995681933 @default.
- W2080237580 cites W2006026205 @default.
- W2080237580 cites W2043192411 @default.
- W2080237580 cites W2048824364 @default.
- W2080237580 cites W2089417403 @default.
- W2080237580 cites W2119466426 @default.
- W2080237580 cites W2315341702 @default.
- W2080237580 cites W2416616318 @default.
- W2080237580 doi "https://doi.org/10.1016/0002-8703(71)90108-6" @default.
- W2080237580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5547437" @default.
- W2080237580 hasPublicationYear "1971" @default.
- W2080237580 type Work @default.
- W2080237580 sameAs 2080237580 @default.
- W2080237580 citedByCount "27" @default.
- W2080237580 countsByYear W20802375802017 @default.
- W2080237580 crossrefType "journal-article" @default.
- W2080237580 hasAuthorship W2080237580A5001793390 @default.
- W2080237580 hasAuthorship W2080237580A5029815474 @default.
- W2080237580 hasAuthorship W2080237580A5029898727 @default.
- W2080237580 hasAuthorship W2080237580A5046006363 @default.
- W2080237580 hasConcept C126322002 @default.
- W2080237580 hasConcept C139940330 @default.
- W2080237580 hasConcept C155710745 @default.
- W2080237580 hasConcept C164705383 @default.
- W2080237580 hasConcept C178853913 @default.
- W2080237580 hasConcept C2777953023 @default.
- W2080237580 hasConcept C2778151854 @default.
- W2080237580 hasConcept C2780802079 @default.
- W2080237580 hasConcept C2780820201 @default.
- W2080237580 hasConcept C39133596 @default.
- W2080237580 hasConcept C42219234 @default.
- W2080237580 hasConcept C58245268 @default.
- W2080237580 hasConcept C71924100 @default.
- W2080237580 hasConcept C84393581 @default.
- W2080237580 hasConceptScore W2080237580C126322002 @default.
- W2080237580 hasConceptScore W2080237580C139940330 @default.
- W2080237580 hasConceptScore W2080237580C155710745 @default.
- W2080237580 hasConceptScore W2080237580C164705383 @default.
- W2080237580 hasConceptScore W2080237580C178853913 @default.
- W2080237580 hasConceptScore W2080237580C2777953023 @default.
- W2080237580 hasConceptScore W2080237580C2778151854 @default.
- W2080237580 hasConceptScore W2080237580C2780802079 @default.
- W2080237580 hasConceptScore W2080237580C2780820201 @default.
- W2080237580 hasConceptScore W2080237580C39133596 @default.
- W2080237580 hasConceptScore W2080237580C42219234 @default.
- W2080237580 hasConceptScore W2080237580C58245268 @default.
- W2080237580 hasConceptScore W2080237580C71924100 @default.
- W2080237580 hasConceptScore W2080237580C84393581 @default.
- W2080237580 hasIssue "3" @default.
- W2080237580 hasLocation W20802375801 @default.
- W2080237580 hasLocation W20802375802 @default.
- W2080237580 hasOpenAccess W2080237580 @default.
- W2080237580 hasPrimaryLocation W20802375801 @default.
- W2080237580 hasRelatedWork W137236334 @default.
- W2080237580 hasRelatedWork W2016846781 @default.
- W2080237580 hasRelatedWork W2030432546 @default.
- W2080237580 hasRelatedWork W2035243957 @default.
- W2080237580 hasRelatedWork W2038856187 @default.
- W2080237580 hasRelatedWork W2087451805 @default.
- W2080237580 hasRelatedWork W2145818775 @default.
- W2080237580 hasRelatedWork W2410981071 @default.
- W2080237580 hasRelatedWork W2412222853 @default.
- W2080237580 hasRelatedWork W2469397725 @default.
- W2080237580 hasVolume "81" @default.
- W2080237580 isParatext "false" @default.
- W2080237580 isRetracted "false" @default.
- W2080237580 magId "2080237580" @default.
- W2080237580 workType "article" @default.