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- W2080239208 endingPage "e201301012" @default.
- W2080239208 startingPage "e201301012" @default.
- W2080239208 abstract "Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme for hydride transfer reactions and a substrate for sirtuins and other NAD(+)-consuming enzymes. The abundance of NAD (+), NAD(+) biosynthetic intermediates, and related nucleotides reflects the metabolic state of cells and tissues. High performance liquid chromatography (HPLC) followed by ultraviolet-visible (UV-Vis) spectroscopic analysis of NAD(+) metabolites does not offer the specificity and sensitivity necessary for robust quantification of complex samples. Thus, we developed a targeted, quantitative assay of the NAD(+) metabolome with the use of HPLC coupled to mass spectrometry. Here we discuss NAD(+) metabolism as well as the technical challenges required for reliable quantification of the NAD(+) metabolites. The new method incorporates new separations and improves upon a previously published method that suffered from the problem of ionization suppression for particular compounds." @default.
- W2080239208 created "2016-06-24" @default.
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- W2080239208 date "2013-01-01" @default.
- W2080239208 modified "2023-09-29" @default.
- W2080239208 title "TARGETED, LCMS-BASED METABOLOMICS FOR QUANTITATIVE MEASUREMENT OF NAD + METABOLITES" @default.
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- W2080239208 doi "https://doi.org/10.5936/csbj.201301012" @default.
- W2080239208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3962138" @default.
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