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- W2080247229 abstract "The vertebrate neural crest migrates from its origin, the neural plate border, to form diverse derivatives. We previously hypothesized that a neural crest gene regulatory network (NC-GRN) guides neural crest formation. Here, we investigate when during evolution this hypothetical network emerged by analyzing neural crest formation in lamprey, a basal extant vertebrate. We identify 50 NC-GRN homologs and use morpholinos to demonstrate a critical role for eight transcriptional regulators. The results reveal conservation in deployment of upstream factors, suggesting that proximal portions of the network arose early in vertebrate evolution and have been conserved for >500 million years. We found biphasic expression of neural crest specifiers and differences in deployment of some specifiers and effectors expected to confer species-specific properties. By testing the collective expression and function of neural crest genes in a single, basal vertebrate, we reveal the ground state of the NC-GRN and resolve ambiguities between model organisms." @default.
- W2080247229 created "2016-06-24" @default.
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- W2080247229 date "2007-09-01" @default.
- W2080247229 modified "2023-09-30" @default.
- W2080247229 title "Ancient Evolutionary Origin of the Neural Crest Gene Regulatory Network" @default.
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- W2080247229 cites W1967195690 @default.
- W2080247229 cites W1976397093 @default.
- W2080247229 cites W1977346307 @default.
- W2080247229 cites W1985368135 @default.
- W2080247229 cites W1986031306 @default.
- W2080247229 cites W1986318992 @default.
- W2080247229 cites W1993176607 @default.
- W2080247229 cites W1995691822 @default.
- W2080247229 cites W1997035797 @default.
- W2080247229 cites W2005110451 @default.
- W2080247229 cites W2011864853 @default.
- W2080247229 cites W2014536457 @default.
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- W2080247229 cites W2047271695 @default.
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- W2080247229 cites W2054367286 @default.
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- W2080247229 cites W2077406721 @default.
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- W2080247229 doi "https://doi.org/10.1016/j.devcel.2007.08.005" @default.
- W2080247229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17765683" @default.
- W2080247229 hasPublicationYear "2007" @default.
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