Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080251738> ?p ?o ?g. }
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- W2080251738 abstract "IL-10 is a suppressive cytokine that has been implicated in the pathophysiology of autoimmune disorders and can be produced by different cell types such as regulatory B-cells. Our previous work showed that under inflammatory condition MZ B-cells differentiated into IL-10 producing cells and contributed to the downregulation of collagen-induced arthritis, while follicular B-cells failed to do so. Based on these observations, we aimed to investigate how inflammatory signals mediated through the BCR, TLR9 and IFN-γ receptors trigger IL-10 production in MZ B-cells but leave FO B-cells unresponsive. We particularly focused on the CREB transcription factor as it is involved in all three signalling cascades and analysed its contribution to IL-10 production. Our results demonstrate that the IL-10 production of MZ B-cells induced by the BCR, TLR9 and IFN-γ receptors is mediated by CREB. We showed that the activation of CREB is prolonged in MZ B-cells while the transcription factor only transiently phosphorylated in FO B-cells. The sustained phosphorylation of CREB is clearly associated with its prolonged binding to molecular partner CBP, whereas inhibition of their association decreased IL-10 production. We assume that sustained activation of CREB is required for IL-10 production by B-cells under inflammatory conditions." @default.
- W2080251738 created "2016-06-24" @default.
- W2080251738 creator A5027470095 @default.
- W2080251738 date "1999-06-01" @default.
- W2080251738 modified "2023-09-27" @default.
- W2080251738 title "Bruton's Tyrosine Kinase Controls a Sustained Calcium Signal Essential for B Lineage Development and Function" @default.
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