Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080254890> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2080254890 endingPage "215" @default.
- W2080254890 startingPage "209" @default.
- W2080254890 abstract "Fetal pig scapular cartilage provides an ideal model to study mammalian cartilage growth in vitro. Growth plate and nongrowth plate cartilages were cultured in serum-free medium for 14 days. These cartilages visibly enlarged, and their wet weight increased over their preincubation weight (86 ± 12% for growth plate; 104 ± 16% for nongrowth plate). Addition of insulin 87 nM, somatomedin C (Sm-C) 10 ng/ml, or triiodothyronine (T 3 ) 10 nM to the medium caused an increase in growth plate cartilage weight and radiolabeled precursor incorporation of [ 3 H]- proline and 35 S0 4 . Insulin and Sm-C also stimulated nongrowth plate cartilge growth, but T 3 had no effect. Since both growth-plate and nongrowth-plate cartilage grew in medium alone, the likelihood that fetal porcine scapular cartilage produced its own growth factor(s) was studied. Conditioned medium was assayed for radioimmunoassayable Sm-C. Sm-C was readily measurable in concentrated conditioned medium (575 ± 20 pg/ml). Since secretion of Sm-like peptides might play a functional role in the growth process, a monoclonal antibody to Sm-C was used to determine whether immuno- neutralization of the Sm-like peptides would inhibit cartilage growth. Addition of anti-Sm-C prevented increases in wet weights of growth plate and nongrowth plate cartilages (47% and 49%, respectively below weights of cartilage incubated in medium alone). These studies demonstrate that fetal mammalian cartilage grows and responds to hormonal stimulation in vitro and suggest that these cartilages make Sm-like peptides that may have a functional role in promoting cartilage growth." @default.
- W2080254890 created "2016-06-24" @default.
- W2080254890 creator A5009066942 @default.
- W2080254890 date "1987-04-01" @default.
- W2080254890 modified "2023-10-16" @default.
- W2080254890 title "Growth of Fetal Porcine Scapular Cartilage In Vitro" @default.
- W2080254890 cites W1497792066 @default.
- W2080254890 cites W1965120152 @default.
- W2080254890 cites W1972319572 @default.
- W2080254890 cites W1974197686 @default.
- W2080254890 cites W1978916721 @default.
- W2080254890 cites W1996487528 @default.
- W2080254890 cites W2001999755 @default.
- W2080254890 cites W2009094802 @default.
- W2080254890 cites W2014493428 @default.
- W2080254890 cites W2023690211 @default.
- W2080254890 cites W2029380858 @default.
- W2080254890 cites W2030522563 @default.
- W2080254890 cites W2050825830 @default.
- W2080254890 cites W2064930094 @default.
- W2080254890 cites W2072159062 @default.
- W2080254890 cites W2083891157 @default.
- W2080254890 cites W2102123572 @default.
- W2080254890 cites W2114870192 @default.
- W2080254890 cites W2124243419 @default.
- W2080254890 cites W2132374234 @default.
- W2080254890 cites W2169916499 @default.
- W2080254890 cites W2171028772 @default.
- W2080254890 cites W322812660 @default.
- W2080254890 doi "https://doi.org/10.1097/00000441-198704000-00001" @default.
- W2080254890 hasPublicationYear "1987" @default.
- W2080254890 type Work @default.
- W2080254890 sameAs 2080254890 @default.
- W2080254890 citedByCount "2" @default.
- W2080254890 crossrefType "journal-article" @default.
- W2080254890 hasAuthorship W2080254890A5009066942 @default.
- W2080254890 hasConcept C105702510 @default.
- W2080254890 hasConcept C126322002 @default.
- W2080254890 hasConcept C134018914 @default.
- W2080254890 hasConcept C16685009 @default.
- W2080254890 hasConcept C170493617 @default.
- W2080254890 hasConcept C172680121 @default.
- W2080254890 hasConcept C185592680 @default.
- W2080254890 hasConcept C202751555 @default.
- W2080254890 hasConcept C2775960820 @default.
- W2080254890 hasConcept C2779234561 @default.
- W2080254890 hasConcept C2780550940 @default.
- W2080254890 hasConcept C2781023255 @default.
- W2080254890 hasConcept C54355233 @default.
- W2080254890 hasConcept C55493867 @default.
- W2080254890 hasConcept C71924100 @default.
- W2080254890 hasConcept C86803240 @default.
- W2080254890 hasConceptScore W2080254890C105702510 @default.
- W2080254890 hasConceptScore W2080254890C126322002 @default.
- W2080254890 hasConceptScore W2080254890C134018914 @default.
- W2080254890 hasConceptScore W2080254890C16685009 @default.
- W2080254890 hasConceptScore W2080254890C170493617 @default.
- W2080254890 hasConceptScore W2080254890C172680121 @default.
- W2080254890 hasConceptScore W2080254890C185592680 @default.
- W2080254890 hasConceptScore W2080254890C202751555 @default.
- W2080254890 hasConceptScore W2080254890C2775960820 @default.
- W2080254890 hasConceptScore W2080254890C2779234561 @default.
- W2080254890 hasConceptScore W2080254890C2780550940 @default.
- W2080254890 hasConceptScore W2080254890C2781023255 @default.
- W2080254890 hasConceptScore W2080254890C54355233 @default.
- W2080254890 hasConceptScore W2080254890C55493867 @default.
- W2080254890 hasConceptScore W2080254890C71924100 @default.
- W2080254890 hasConceptScore W2080254890C86803240 @default.
- W2080254890 hasIssue "4" @default.
- W2080254890 hasLocation W20802548901 @default.
- W2080254890 hasOpenAccess W2080254890 @default.
- W2080254890 hasPrimaryLocation W20802548901 @default.
- W2080254890 hasRelatedWork W1973833989 @default.
- W2080254890 hasRelatedWork W1993795923 @default.
- W2080254890 hasRelatedWork W2002562299 @default.
- W2080254890 hasRelatedWork W2045448786 @default.
- W2080254890 hasRelatedWork W2086993677 @default.
- W2080254890 hasRelatedWork W2091151050 @default.
- W2080254890 hasRelatedWork W2094857026 @default.
- W2080254890 hasRelatedWork W2099734673 @default.
- W2080254890 hasRelatedWork W2141521254 @default.
- W2080254890 hasRelatedWork W2156499933 @default.
- W2080254890 hasVolume "293" @default.
- W2080254890 isParatext "false" @default.
- W2080254890 isRetracted "false" @default.
- W2080254890 magId "2080254890" @default.
- W2080254890 workType "article" @default.