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- W2080260149 abstract "1. Antibodies directed against bovine brain or bovine pancreatic ribonucleases (EC 3.1.4.22, ribonucleate 3′-pyrimidino-oligonucletidohydrolase) have been shown to be highly specific and sensitive in enzyme quantitation. In competitive binding radioimmunoassays, cross-reactivity with the heterologous ribonucleasesis less than 0.1% and sensitivity for detection of the homologous enzyme is 1–10 ng per assay, comparable to enzymatic analytic l procedures. 2. Immunological analysis of each enzyme in crude extracts of brain and pancreas accurately measures the level of each enzyme. Radioimmunoassay also shows materials that cross-react with each antibody preparation in extracts of liver, kidney, and seminal vesicles, but in most tissues the level of immunological cross-reactivity is not sufficient to account for all enzymatic activity. Instead, these tissues have one or more RNases which are structurally different from either the brain or pancreatic enzymes. 3. Gel filtration of extracts usually separates pancreatic-like and brain-like immunological cross- reactivity. Ribonuclease(s) which are not closely related to either the brain or pancreatic enzymes are sometimes apparent in the elution patterns. 4. Cross-reactivaty of anti-bovine brain ribonuclease with extracts of pig, rat, chicken, or turtle brain is very low. It is suggested that structural evolution of the brain ribonucleases may have been rapid, as previously suggested for pancreatic ribonucleases." @default.
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- W2080260149 date "1981-01-01" @default.
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- W2080260149 title "Bovine ribonucleases: Identification of tissue-specific enzymes by immunological methods" @default.
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- W2080260149 doi "https://doi.org/10.1016/0305-0491(81)90325-4" @default.
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