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- W2080263257 abstract "An in vitro method for measuring phenobarbital (PB) induction of microsomal cytochrome P -450 monooxygenases ( P -450 monooxygenases) in fat bodies (FB) from 2- to 3-day-old adult house flies was developed. Adult house fly FB retain expression of total cytochrome P -450s, cytochrome P -450 lpr , cytochrome b 5 , P -450 reductase, and 7-ethoxycoumarin O -deethylation (ECOD) activity up to 36 h in culture. However, the basal level of P -450 monooxygenases was slightly lower in cultured FB compared to fresh FB. In vitro , PB dramatically induced the ECOD activity in a dose-dependent manner with an EC 50 of 0.07 or 0.1 mM on a per mg protein or per FB basis, respectively. The induction response was maximal at 36 h and decreased at later times. PB induced the levels of cytochrome P -450 lpr and total cytochrome P -450s, but caused only a slight increase in cytochrome b 5 or P -450 reductase levels. In vitro/in vivo differences in PB inducibility of P -450 monooxygenases existed. Lower level of ECOD activity and higher levels of total cytochrome P -450s, cytochrome b 5 and P -450 reductase activity were induced in vitro compared to in vivo . These results suggest that the house fly FB culture can be used as an in vitro model for study of induction in house flies." @default.
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- W2080263257 date "1992-10-01" @default.
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- W2080263257 title "In vitro induction of microsomal cytochrome P-450 monooxygenases by phenobarbital in fat bodies of adult house fly, Musca domestica L." @default.
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- W2080263257 doi "https://doi.org/10.1016/0965-1748(92)90048-j" @default.
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