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• W2080266502 abstract "The purpose of this study was to develop a novel, drug-free therapy that can reduce the over-accumulation of cariogenic bacteria on dental surfaces.We designed and synthesized a polyethylene glycol (PEG)-based hydrophilic copolymer functionalized with a pyrophosphate (PPi) tooth-binding anchor using click chemistry. The polymer was then evaluated for hydroxyapatite (HA) binding kinetics and capability of reducing bacteria adhesion to artificial tooth surface.The PPi-PEG copolymer can effectively inhibit salivary protein adsorption after rapid binding to an artificial tooth surface. As a result, the in vitro S. mutans adhesion study showed that the PPi-PEG copolymer can inhibit saliva protein-promoted S. mutans adhesion through the creation of a neutral, hydrophilic layer on the artificial tooth surface.The results suggested the potential application of a PPi-PEG copolymer as a drug-free alternative to current antimicrobial therapy for caries prevention." @default.
• W2080266502 created "2016-06-24" @default.
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• W2080266502 date "2014-05-15" @default.
• W2080266502 modified "2023-09-26" @default.
• W2080266502 title "The Development of Drug-Free Therapy for Prevention of Dental Caries" @default.
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• W2080266502 doi "https://doi.org/10.1007/s11095-014-1396-1" @default.
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