FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080267776> ?p ?o ?g. }

• W2080267776 abstract "Both experimental and clinical studies suggest that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. This oxidative stress leads to β-cell destruction by apoptosis. Hence exploring agents modulating oxidative stress is an effective strategy in the treatment of both Type I and Type II diabetes. Plants are a major source of anti-oxidants and exert protective effects against oxidative stress in biological systems. Phyllanthus emblica, Curcuma longa and Tinospora cordifolia are three such plants widely used in Ayurveda for their anti-hyperglycemic activity. Additionally their anti-oxidant properties have been scientifically validated in various experimental in vitro and in vivo models. Hence the present in vitro study was planned to assess whether the anti-hyperglycemic effects of the hydro-alcoholic extracts of Phyllanthus emblica (Pe) and Curcuma longa (Cl) and aqueous extract of Tinospora cordifolia (Tc) are mediated through their antioxidant and/or anti-apoptotic property in a streptozotocin induced stress model.RINm5F cell line was used as a model of pancreatic β-cells against stress induced by streptozotocin (2 mM). Non-toxic concentrations of the plant extracts were identified using MTT assay. Lipid peroxidation through MDA release, modulation of apoptosis and insulin release were the variables measured to assess streptozotocin induced damage and protection afforded by the plant extracts.All 3 plants extracts significantly inhibited MDA release from RIN cells indicating protective effect against STZ induced oxidative damage. They also exhibited a dose dependent anti-apoptotic effect as seen by a decrease in the sub G0 population in response to STZ. None of the plant extracts affected insulin secretion from the cells to a great extent.The present study thus demonstrated that the protective effect of the selected medicinal plants against oxidative stress induced by STZ in vitro, which was exerted through their anti-oxidant and anti-apoptotic actions." @default.
• W2080267776 created "2016-06-24" @default.
• W2080267776 creator A5024884485 @default.
• W2080267776 creator A5036550403 @default.
• W2080267776 creator A5040782924 @default.
• W2080267776 date "2013-10-05" @default.
• W2080267776 modified "2023-10-14" @default.
• W2080267776 title "Do plants mediate their anti-diabetic effects through anti-oxidant and anti-apoptotic actions? an in vitro assay of 3 Indian medicinal plants" @default.
• W2080267776 cites W143638043 @default.
• W2080267776 cites W1860003112 @default.
• W2080267776 cites W1905082515 @default.
• W2080267776 cites W1971953001 @default.
• W2080267776 cites W1998401231 @default.
• W2080267776 cites W2005754586 @default.
• W2080267776 cites W2023150880 @default.
• W2080267776 cites W2026352837 @default.
• W2080267776 cites W2033447249 @default.
• W2080267776 cites W2039913200 @default.
• W2080267776 cites W2044221800 @default.
• W2080267776 cites W2049104737 @default.
• W2080267776 cites W2049321949 @default.
• W2080267776 cites W2049465069 @default.
• W2080267776 cites W2061092787 @default.
• W2080267776 cites W2064889863 @default.
• W2080267776 cites W2066659788 @default.
• W2080267776 cites W2067735038 @default.
• W2080267776 cites W2069819213 @default.
• W2080267776 cites W2075008661 @default.
• W2080267776 cites W2090304781 @default.
• W2080267776 cites W2094943143 @default.
• W2080267776 cites W2098466711 @default.
• W2080267776 cites W2110121513 @default.
• W2080267776 cites W2122032057 @default.
• W2080267776 cites W2125982755 @default.
• W2080267776 cites W2131976191 @default.
• W2080267776 cites W2135434526 @default.
• W2080267776 cites W2152692585 @default.
• W2080267776 cites W2167543749 @default.
• W2080267776 cites W2169790726 @default.
• W2080267776 cites W2316565714 @default.
• W2080267776 cites W2127881223 @default.
• W2080267776 doi "https://doi.org/10.1186/1472-6882-13-257" @default.
• W2080267776 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3852064" @default.
• W2080267776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24093976" @default.
• W2080267776 hasPublicationYear "2013" @default.
• W2080267776 type Work @default.
• W2080267776 sameAs 2080267776 @default.
• W2080267776 citedByCount "22" @default.
• W2080267776 countsByYear W20802677762014 @default.
• W2080267776 countsByYear W20802677762015 @default.
• W2080267776 countsByYear W20802677762016 @default.
• W2080267776 countsByYear W20802677762017 @default.
• W2080267776 countsByYear W20802677762019 @default.
• W2080267776 countsByYear W20802677762020 @default.
• W2080267776 countsByYear W20802677762021 @default.
• W2080267776 countsByYear W20802677762022 @default.
• W2080267776 crossrefType "journal-article" @default.
• W2080267776 hasAuthorship W2080267776A5024884485 @default.
• W2080267776 hasAuthorship W2080267776A5036550403 @default.
• W2080267776 hasAuthorship W2080267776A5040782924 @default.
• W2080267776 hasBestOaLocation W20802677761 @default.
• W2080267776 hasConcept C134018914 @default.
• W2080267776 hasConcept C185592680 @default.
• W2080267776 hasConcept C190283241 @default.
• W2080267776 hasConcept C2776151105 @default.
• W2080267776 hasConcept C2777230291 @default.
• W2080267776 hasConcept C2778004101 @default.
• W2080267776 hasConcept C2778523797 @default.
• W2080267776 hasConcept C2779280383 @default.
• W2080267776 hasConcept C2780783641 @default.
• W2080267776 hasConcept C2780829032 @default.
• W2080267776 hasConcept C2908647359 @default.
• W2080267776 hasConcept C2910151965 @default.
• W2080267776 hasConcept C55493867 @default.
• W2080267776 hasConcept C555293320 @default.
• W2080267776 hasConcept C556039675 @default.
• W2080267776 hasConcept C71924100 @default.
• W2080267776 hasConcept C98274493 @default.
• W2080267776 hasConcept C99454951 @default.
• W2080267776 hasConceptScore W2080267776C134018914 @default.
• W2080267776 hasConceptScore W2080267776C185592680 @default.
• W2080267776 hasConceptScore W2080267776C190283241 @default.
• W2080267776 hasConceptScore W2080267776C2776151105 @default.
• W2080267776 hasConceptScore W2080267776C2777230291 @default.
• W2080267776 hasConceptScore W2080267776C2778004101 @default.
• W2080267776 hasConceptScore W2080267776C2778523797 @default.
• W2080267776 hasConceptScore W2080267776C2779280383 @default.
• W2080267776 hasConceptScore W2080267776C2780783641 @default.
• W2080267776 hasConceptScore W2080267776C2780829032 @default.
• W2080267776 hasConceptScore W2080267776C2908647359 @default.
• W2080267776 hasConceptScore W2080267776C2910151965 @default.
• W2080267776 hasConceptScore W2080267776C55493867 @default.
• W2080267776 hasConceptScore W2080267776C555293320 @default.
• W2080267776 hasConceptScore W2080267776C556039675 @default.
• W2080267776 hasConceptScore W2080267776C71924100 @default.
• W2080267776 hasConceptScore W2080267776C98274493 @default.
• W2080267776 hasConceptScore W2080267776C99454951 @default.
• W2080267776 hasIssue "1" @default.
• W2080267776 hasLocation W20802677761 @default.
• W2080267776 hasLocation W20802677762 @default.

• next