Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080269820> ?p ?o ?g. }
- W2080269820 endingPage "1109" @default.
- W2080269820 startingPage "1090" @default.
- W2080269820 abstract "The importance of hepatic uptake transporters in drug clearance is well recognized. The subject is reviewed with the intention of providing an overview of the concepts in order to link the increasing knowledge of transporter-mediated uptake into established models of hepatic clearance. In order to understand and quantify their impact, models of hepatic elimination that incorporate permeability barriers are required. Models that include both active and passive uptake into hepatocytes are discussed and simulations of the influence of active uptake and passive diffusion on hepatic clearance are presented. The advantages and weaknesses of a number of in vitro assays of hepatic uptake are described, and their ability to predict hepatic clearance is reviewed." @default.
- W2080269820 created "2016-06-24" @default.
- W2080269820 creator A5049209704 @default.
- W2080269820 creator A5079424977 @default.
- W2080269820 creator A5081863560 @default.
- W2080269820 creator A5090060604 @default.
- W2080269820 date "2007-11-01" @default.
- W2080269820 modified "2023-10-17" @default.
- W2080269820 title "<b><i>In vitro</i></b>–<b><i>in vivo</i></b>extrapolation of hepatic clearance involving active uptake: Theoretical and experimental aspects" @default.
- W2080269820 cites W1487737816 @default.
- W2080269820 cites W1538056146 @default.
- W2080269820 cites W1568560565 @default.
- W2080269820 cites W186800207 @default.
- W2080269820 cites W1970559437 @default.
- W2080269820 cites W1980136116 @default.
- W2080269820 cites W1991652499 @default.
- W2080269820 cites W1993047099 @default.
- W2080269820 cites W2009570004 @default.
- W2080269820 cites W2013322396 @default.
- W2080269820 cites W2015349672 @default.
- W2080269820 cites W2020371789 @default.
- W2080269820 cites W2020504510 @default.
- W2080269820 cites W2026881218 @default.
- W2080269820 cites W2028573860 @default.
- W2080269820 cites W2032353075 @default.
- W2080269820 cites W2032865438 @default.
- W2080269820 cites W2035233312 @default.
- W2080269820 cites W2039141364 @default.
- W2080269820 cites W2040411965 @default.
- W2080269820 cites W2040816497 @default.
- W2080269820 cites W2042506106 @default.
- W2080269820 cites W2046788693 @default.
- W2080269820 cites W2048521506 @default.
- W2080269820 cites W2052592379 @default.
- W2080269820 cites W2059973305 @default.
- W2080269820 cites W2061152607 @default.
- W2080269820 cites W2064413682 @default.
- W2080269820 cites W2065507203 @default.
- W2080269820 cites W2066382275 @default.
- W2080269820 cites W2072784247 @default.
- W2080269820 cites W2076027662 @default.
- W2080269820 cites W2076385318 @default.
- W2080269820 cites W2076546070 @default.
- W2080269820 cites W2078158358 @default.
- W2080269820 cites W2081750550 @default.
- W2080269820 cites W2091451013 @default.
- W2080269820 cites W2098154721 @default.
- W2080269820 cites W2103855721 @default.
- W2080269820 cites W2105517464 @default.
- W2080269820 cites W2116796907 @default.
- W2080269820 cites W2118625948 @default.
- W2080269820 cites W2121001657 @default.
- W2080269820 cites W2124775757 @default.
- W2080269820 cites W2131708092 @default.
- W2080269820 cites W2132603119 @default.
- W2080269820 cites W2133677036 @default.
- W2080269820 cites W2140054248 @default.
- W2080269820 cites W2143189887 @default.
- W2080269820 cites W2145123754 @default.
- W2080269820 cites W2145804243 @default.
- W2080269820 cites W2149701488 @default.
- W2080269820 cites W2156445661 @default.
- W2080269820 cites W2157772258 @default.
- W2080269820 cites W2162138804 @default.
- W2080269820 cites W2171671443 @default.
- W2080269820 cites W4253344482 @default.
- W2080269820 cites W4317926875 @default.
- W2080269820 cites W74649421 @default.
- W2080269820 cites W97964894 @default.
- W2080269820 doi "https://doi.org/10.3109/00498250701557266" @default.
- W2080269820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17968738" @default.
- W2080269820 hasPublicationYear "2007" @default.
- W2080269820 type Work @default.
- W2080269820 sameAs 2080269820 @default.
- W2080269820 citedByCount "15" @default.
- W2080269820 countsByYear W20802698202012 @default.
- W2080269820 countsByYear W20802698202014 @default.
- W2080269820 countsByYear W20802698202015 @default.
- W2080269820 countsByYear W20802698202016 @default.
- W2080269820 countsByYear W20802698202018 @default.
- W2080269820 countsByYear W20802698202019 @default.
- W2080269820 countsByYear W20802698202021 @default.
- W2080269820 countsByYear W20802698202023 @default.
- W2080269820 crossrefType "journal-article" @default.
- W2080269820 hasAuthorship W2080269820A5049209704 @default.
- W2080269820 hasAuthorship W2080269820A5079424977 @default.
- W2080269820 hasAuthorship W2080269820A5081863560 @default.
- W2080269820 hasAuthorship W2080269820A5090060604 @default.
- W2080269820 hasConcept C104317684 @default.
- W2080269820 hasConcept C149011108 @default.
- W2080269820 hasConcept C150903083 @default.
- W2080269820 hasConcept C185592680 @default.
- W2080269820 hasConcept C202751555 @default.
- W2080269820 hasConcept C207001950 @default.
- W2080269820 hasConcept C55493867 @default.
- W2080269820 hasConcept C86803240 @default.
- W2080269820 hasConcept C98274493 @default.
- W2080269820 hasConceptScore W2080269820C104317684 @default.