Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080271337> ?p ?o ?g. }
- W2080271337 endingPage "317" @default.
- W2080271337 startingPage "307" @default.
- W2080271337 abstract "We previously demonstrated the capacity of GAS1 (Growth Arrest Specific 1) to inhibit the growth of gliomas by blocking the GDNF-RET signaling pathway. Here, we show that a soluble form of GAS1 (tGAS1), decreases the number of viable MDA MB 231 human breast cancer cells, acting in both autocrine and paracrine manners when secreted from producing cells. Moreover, tGAS1 inhibits the growth of tumors implanted in female nu/nu mice through a RET-independent mechanism which involves interfering with the Artemin (ARTN)-GFRα3-(GDNF Family Receptor alpha 3) mediated intracellular signaling and the activation of ERK. In addition, we observed that the presence of tGAS1 reduces the vascularization of implanted tumors, by preventing the migration of endothelial cells. The present results support a potential adjuvant role for tGAS1 in the treatment of breast cancer, by detaining tumor growth and inhibiting angiogenesis." @default.
- W2080271337 created "2016-06-24" @default.
- W2080271337 creator A5022629209 @default.
- W2080271337 creator A5031349870 @default.
- W2080271337 creator A5040304325 @default.
- W2080271337 creator A5070277021 @default.
- W2080271337 creator A5077461434 @default.
- W2080271337 creator A5082129453 @default.
- W2080271337 date "2014-10-01" @default.
- W2080271337 modified "2023-10-17" @default.
- W2080271337 title "A soluble form of GAS1 inhibits tumor growth and angiogenesis in a triple negative breast cancer model" @default.
- W2080271337 cites W155933052 @default.
- W2080271337 cites W1971208141 @default.
- W2080271337 cites W1981491762 @default.
- W2080271337 cites W1981775117 @default.
- W2080271337 cites W1982570011 @default.
- W2080271337 cites W1989381407 @default.
- W2080271337 cites W1991766942 @default.
- W2080271337 cites W1994510756 @default.
- W2080271337 cites W1996233120 @default.
- W2080271337 cites W1996342148 @default.
- W2080271337 cites W2003015610 @default.
- W2080271337 cites W2009259931 @default.
- W2080271337 cites W2013742609 @default.
- W2080271337 cites W2032119575 @default.
- W2080271337 cites W2033433548 @default.
- W2080271337 cites W2033467450 @default.
- W2080271337 cites W2033825051 @default.
- W2080271337 cites W2045028629 @default.
- W2080271337 cites W2049469582 @default.
- W2080271337 cites W2059192510 @default.
- W2080271337 cites W2059591019 @default.
- W2080271337 cites W2062289724 @default.
- W2080271337 cites W2074469498 @default.
- W2080271337 cites W2083647855 @default.
- W2080271337 cites W2086790644 @default.
- W2080271337 cites W2087793454 @default.
- W2080271337 cites W2089370460 @default.
- W2080271337 cites W2095893831 @default.
- W2080271337 cites W2097607174 @default.
- W2080271337 cites W2101276124 @default.
- W2080271337 cites W2112145459 @default.
- W2080271337 cites W2112377187 @default.
- W2080271337 cites W2117839670 @default.
- W2080271337 cites W2119770922 @default.
- W2080271337 cites W2120420390 @default.
- W2080271337 cites W2121060162 @default.
- W2080271337 cites W2126455523 @default.
- W2080271337 cites W2126575512 @default.
- W2080271337 cites W2130052626 @default.
- W2080271337 cites W2143077434 @default.
- W2080271337 cites W2154675721 @default.
- W2080271337 cites W2159826153 @default.
- W2080271337 doi "https://doi.org/10.1016/j.yexcr.2014.06.016" @default.
- W2080271337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24992044" @default.
- W2080271337 hasPublicationYear "2014" @default.
- W2080271337 type Work @default.
- W2080271337 sameAs 2080271337 @default.
- W2080271337 citedByCount "29" @default.
- W2080271337 countsByYear W20802713372015 @default.
- W2080271337 countsByYear W20802713372016 @default.
- W2080271337 countsByYear W20802713372017 @default.
- W2080271337 countsByYear W20802713372018 @default.
- W2080271337 countsByYear W20802713372019 @default.
- W2080271337 countsByYear W20802713372020 @default.
- W2080271337 countsByYear W20802713372021 @default.
- W2080271337 countsByYear W20802713372022 @default.
- W2080271337 countsByYear W20802713372023 @default.
- W2080271337 crossrefType "journal-article" @default.
- W2080271337 hasAuthorship W2080271337A5022629209 @default.
- W2080271337 hasAuthorship W2080271337A5031349870 @default.
- W2080271337 hasAuthorship W2080271337A5040304325 @default.
- W2080271337 hasAuthorship W2080271337A5070277021 @default.
- W2080271337 hasAuthorship W2080271337A5077461434 @default.
- W2080271337 hasAuthorship W2080271337A5082129453 @default.
- W2080271337 hasConcept C121608353 @default.
- W2080271337 hasConcept C128240485 @default.
- W2080271337 hasConcept C160539049 @default.
- W2080271337 hasConcept C170493617 @default.
- W2080271337 hasConcept C185856081 @default.
- W2080271337 hasConcept C2780110267 @default.
- W2080271337 hasConcept C2780394083 @default.
- W2080271337 hasConcept C502942594 @default.
- W2080271337 hasConcept C530470458 @default.
- W2080271337 hasConcept C54355233 @default.
- W2080271337 hasConcept C55493867 @default.
- W2080271337 hasConcept C57074206 @default.
- W2080271337 hasConcept C62478195 @default.
- W2080271337 hasConcept C7876069 @default.
- W2080271337 hasConcept C86803240 @default.
- W2080271337 hasConcept C95444343 @default.
- W2080271337 hasConcept C96232424 @default.
- W2080271337 hasConceptScore W2080271337C121608353 @default.
- W2080271337 hasConceptScore W2080271337C128240485 @default.
- W2080271337 hasConceptScore W2080271337C160539049 @default.
- W2080271337 hasConceptScore W2080271337C170493617 @default.
- W2080271337 hasConceptScore W2080271337C185856081 @default.
- W2080271337 hasConceptScore W2080271337C2780110267 @default.