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- W2080280910 abstract "The sustained overproduction of reactive oxygen and nitrogen species results in an imbalance of cellular prooxidant-antioxidant systems and is implicated in numerous disease states, including alcoholic liver disease, cancer, neurological disorders, inflammation, and cardiovascular disease. The accumulation of reactive aldehydes resulting from sustained oxidative stress and lipid peroxidation is an underlying factor in the development of these pathologies. Determining the biochemical factors that elicit cellular responses resulting from protein carbonylation remains a key element to developing therapeutic approaches and ameliorating disease pathologies. This review details our current understanding of the generation of reactive aldehydes via lipid peroxidation resulting in protein carbonylation, focusing on pathophysiologic factors associated with 4-hydroxynonenal-protein modification. Additionally, an overview of in vitro and in vivo model systems used to study the physiologic impact of protein carbonylation is presented. Finally, an update of the methods commonly used in characterizing protein modification by reactive aldehydes provides an overview of isolation techniques, mass spectrometry, and computational biology. It is apparent that research in this area employing state-of-the-art proteomics, mass spectrometry, and computational biology is rapidly evolving, yielding foundational knowledge concerning the molecular mechanisms of protein carbonylation and its relation to a spectrum of diseases associated with oxidative stress." @default.
- W2080280910 created "2016-06-24" @default.
- W2080280910 creator A5045433486 @default.
- W2080280910 creator A5088828968 @default.
- W2080280910 date "2011-08-18" @default.
- W2080280910 modified "2023-10-18" @default.
- W2080280910 title "Exploring the Biology of Lipid Peroxidation-Derived Protein Carbonylation" @default.
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- W2080280910 doi "https://doi.org/10.1021/tx200169n" @default.
- W2080280910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3178011" @default.
- W2080280910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21812433" @default.
- W2080280910 hasPublicationYear "2011" @default.
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