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• W2080281567 abstract "Abstract Activity‐dependent bulk endocytosis ( ADBE ) is the dominant synaptic vesicle ( SV ) endocytosis mode in central nerve terminals during intense neuronal activity. By definition this mode is triggered by neuronal activity; however, key questions regarding its mechanism of activation remain unaddressed. To determine the basic requirements for ADBE triggering in central nerve terminals, we decoupled SV fusion events from activity‐dependent calcium influx using either clostridial neurotoxins or buffering of intracellular calcium. ADBE was monitored both optically and morphologically by observing uptake of the fluid phase markers tetramethylrhodamine‐dextran and horse radish peroxidase respectively. Ablation of SV fusion with tetanus toxin resulted in the arrest of ADBE , but had no effect on other calcium‐dependent events such as activity‐dependent dynamin I dephosphorylation, indicating that SV exocytosis is necessary for triggering. Furthermore, the calcium chelator EGTA abolished ADBE while leaving SV exocytosis intact, demonstrating that ADBE is triggered by intracellular free calcium increases outside the active zone. Activity‐dependent dynamin I dephosphorylation was also arrested in EGTA ‐treated neurons, consistent with its proposed role in triggering ADBE . Thus, SV fusion and increased cytoplasmic free calcium are both necessary but not sufficient individually to trigger ADBE . image Activity‐dependent bulk endocytosis (ADBE) is the dominant synaptic vesicle (SV) endocytosis mode in central nerve terminals during intense neuronal activity. To determine the minimal requirements for ADBE triggering, we decoupled SV fusion events from activity‐dependent calcium influx using either clostridial neurotoxins or buffering of intracellular calcium. We found that SV fusion and increased cytoplasmic free calcium are both necessary but not sufficient to trigger ADBE." @default.
• W2080281567 created "2016-06-24" @default.
• W2080281567 creator A5018001413 @default.
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• W2080281567 date "2015-05-14" @default.
• W2080281567 modified "2023-10-03" @default.
• W2080281567 title "Synaptic vesicle exocytosis and increased cytosolic calcium are both necessary but not sufficient for activity-dependent bulk endocytosis" @default.
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• W2080281567 doi "https://doi.org/10.1111/jnc.13132" @default.
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