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• W2080287136 startingPage "137" @default.
• W2080287136 abstract "Viral infection is detected by the host innate immune system. Innate immune cells such as dendritic cells and macrophages detect nucleic acids derived from viruses through pattern recognition receptors (PRRs). Viral recognition by PRRs initiates the activation of signaling pathways that lead to production of type I interferon and inflammatory cytokines, which are important for the elimination of viruses. Two types of PRRs that recognize viral nucleic acids, Toll-like receptors (TLR) and RIG-I-like RNA helicases (RLH), have been identified. Of the TLRs, TLR3 recognizes viral double-stranded (ds) RNA, TLR7 and human TLR8 identify viral single-stranded (ss) RNA and TLR9 detects viral DNA. TLRs are located in endosomal compartments, whereas RLH are present in the cytoplasm where they detect viral dsRNA or ssRNA. Here we review the role of TLRs and RLHs in the antiviral innate immune response." @default.
• W2080287136 created "2016-06-24" @default.
• W2080287136 creator A5018553332 @default.
• W2080287136 creator A5062825404 @default.
• W2080287136 date "2006-12-26" @default.
• W2080287136 modified "2023-10-14" @default.
• W2080287136 title "Antiviral Signaling Through Pattern Recognition Receptors" @default.
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• W2080287136 doi "https://doi.org/10.1093/jb/mvm032" @default.
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