Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080290112> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2080290112 endingPage "7537" @default.
- W2080290112 startingPage "7533" @default.
- W2080290112 abstract "We investigated whether staphylococcal exotoxins (SEs), in addition to their capacity to induce T-cell activation restricted by the T-cell receptor (TCR) beta-chain variable region, can deliver an activation signal to human T-cell clones through major histocompatibility complex (MHC) class II molecules. Eleven human T-cell clones (9 alpha beta TCR and 2 gamma delta TCR clones) of different antigenic specificities were tested for their capacity to proliferate in response to toxic shock syndrome toxin 1 (TSST-1) and two SEs, SEA and SEB. In the absence of accessory cells, only 4 alpha beta TCR clones were stimulated to proliferate, each by a single SE, and to mobilize intracellular free Ca2+ in response to that SE, events indicative of TCR engagement and, presumably, recognition restricted by the beta-chain variable region. In the presence of accessory cells, each of the 11 T-cell clones was stimulated to proliferate by any one of the three SEs tested. This apparently TCR-unrestricted SE-mediated polyclonal proliferation of T-cell clones occurred in the absence of an increase in intracellular free Ca2+ and was not dependent on the presence of MHC class II expression on accessory cells. In contrast, SE-mediated polyclonal proliferation did not occur in 3 alpha beta TCR clones derived from an MHC class II-deficient patient. Furthermore, all of the three SEs induced the proliferation of 4 natural-killer-cell clones, suggesting that expression of TCR/CD3 complex is not essential for SE-mediated polyclonal proliferation of activated lymphocytes. These results indicate that MHC class II molecules transduce activation signals to human T- and natural-killer-cell clones." @default.
- W2080290112 created "2016-06-24" @default.
- W2080290112 creator A5013756173 @default.
- W2080290112 creator A5048379219 @default.
- W2080290112 creator A5089955013 @default.
- W2080290112 date "1991-09-01" @default.
- W2080290112 modified "2023-09-25" @default.
- W2080290112 title "Staphylococcal exotoxins deliver activation signals to human T-cell clones via major histocompatibility complex class II molecules." @default.
- W2080290112 cites W1493248673 @default.
- W2080290112 cites W1504038693 @default.
- W2080290112 cites W1516186972 @default.
- W2080290112 cites W1528726881 @default.
- W2080290112 cites W1564692190 @default.
- W2080290112 cites W1584508530 @default.
- W2080290112 cites W1679756706 @default.
- W2080290112 cites W1845214715 @default.
- W2080290112 cites W1966300007 @default.
- W2080290112 cites W1971706796 @default.
- W2080290112 cites W1975058955 @default.
- W2080290112 cites W2000877921 @default.
- W2080290112 cites W2004118180 @default.
- W2080290112 cites W2007735588 @default.
- W2080290112 cites W2024273721 @default.
- W2080290112 cites W2034181842 @default.
- W2080290112 cites W2056021589 @default.
- W2080290112 cites W2056246453 @default.
- W2080290112 cites W2059273877 @default.
- W2080290112 cites W2063096720 @default.
- W2080290112 cites W2066527693 @default.
- W2080290112 cites W2071743575 @default.
- W2080290112 cites W2079712794 @default.
- W2080290112 cites W2080966713 @default.
- W2080290112 cites W2142490832 @default.
- W2080290112 cites W2162010631 @default.
- W2080290112 doi "https://doi.org/10.1073/pnas.88.17.7533" @default.
- W2080290112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/52335" @default.
- W2080290112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1881894" @default.
- W2080290112 hasPublicationYear "1991" @default.
- W2080290112 type Work @default.
- W2080290112 sameAs 2080290112 @default.
- W2080290112 citedByCount "46" @default.
- W2080290112 countsByYear W20802901122013 @default.
- W2080290112 countsByYear W20802901122017 @default.
- W2080290112 crossrefType "journal-article" @default.
- W2080290112 hasAuthorship W2080290112A5013756173 @default.
- W2080290112 hasAuthorship W2080290112A5048379219 @default.
- W2080290112 hasAuthorship W2080290112A5089955013 @default.
- W2080290112 hasBestOaLocation W20802901122 @default.
- W2080290112 hasConcept C114684123 @default.
- W2080290112 hasConcept C147483822 @default.
- W2080290112 hasConcept C153911025 @default.
- W2080290112 hasConcept C167672396 @default.
- W2080290112 hasConcept C19317047 @default.
- W2080290112 hasConcept C203014093 @default.
- W2080290112 hasConcept C207936829 @default.
- W2080290112 hasConcept C2776090121 @default.
- W2080290112 hasConcept C2778814158 @default.
- W2080290112 hasConcept C36333154 @default.
- W2080290112 hasConcept C86803240 @default.
- W2080290112 hasConcept C8891405 @default.
- W2080290112 hasConcept C95444343 @default.
- W2080290112 hasConcept C956191 @default.
- W2080290112 hasConceptScore W2080290112C114684123 @default.
- W2080290112 hasConceptScore W2080290112C147483822 @default.
- W2080290112 hasConceptScore W2080290112C153911025 @default.
- W2080290112 hasConceptScore W2080290112C167672396 @default.
- W2080290112 hasConceptScore W2080290112C19317047 @default.
- W2080290112 hasConceptScore W2080290112C203014093 @default.
- W2080290112 hasConceptScore W2080290112C207936829 @default.
- W2080290112 hasConceptScore W2080290112C2776090121 @default.
- W2080290112 hasConceptScore W2080290112C2778814158 @default.
- W2080290112 hasConceptScore W2080290112C36333154 @default.
- W2080290112 hasConceptScore W2080290112C86803240 @default.
- W2080290112 hasConceptScore W2080290112C8891405 @default.
- W2080290112 hasConceptScore W2080290112C95444343 @default.
- W2080290112 hasConceptScore W2080290112C956191 @default.
- W2080290112 hasIssue "17" @default.
- W2080290112 hasLocation W20802901121 @default.
- W2080290112 hasLocation W20802901122 @default.
- W2080290112 hasLocation W20802901123 @default.
- W2080290112 hasLocation W20802901124 @default.
- W2080290112 hasOpenAccess W2080290112 @default.
- W2080290112 hasPrimaryLocation W20802901121 @default.
- W2080290112 hasRelatedWork W1966446974 @default.
- W2080290112 hasRelatedWork W1969665116 @default.
- W2080290112 hasRelatedWork W2015361131 @default.
- W2080290112 hasRelatedWork W2028104451 @default.
- W2080290112 hasRelatedWork W2059422010 @default.
- W2080290112 hasRelatedWork W2065430316 @default.
- W2080290112 hasRelatedWork W2080290112 @default.
- W2080290112 hasRelatedWork W2139478235 @default.
- W2080290112 hasRelatedWork W2155684035 @default.
- W2080290112 hasRelatedWork W2170420780 @default.
- W2080290112 hasVolume "88" @default.
- W2080290112 isParatext "false" @default.
- W2080290112 isRetracted "false" @default.
- W2080290112 magId "2080290112" @default.
- W2080290112 workType "article" @default.