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• W2080291012 endingPage "213" @default.
• W2080291012 startingPage "199" @default.
• W2080291012 abstract "The radial localization and properties of elementary calcium release events (puffs) were studied in Xenopus oocytes using a confocal microscope equipped with a piezoelectric focussing unit to allow rapid (>100 Hz) imaging of calcium signals along a radial line into the cell with a spatial resolution of <0.7 micrometer. Weak photorelease of caged inositol 1,4,5-trisphosphate (InsP3) evoked puffs arising predominantly within a 6-micrometer thick band located within a few micrometers of the cell surface. Approximately 25% of puffs had a restricted radial spread, consistent with calcium release from a single site. Most puffs, however, exhibited a greater radial spread (3.25 micrometer), likely involving recruitment of radially neighboring release sites. Calcium waves evoked by just suprathreshold stimuli exhibited radial calcium distributions consistent with inward diffusion of calcium liberated at puff sites, whereas stronger flashes evoked strong, short-latency signals at depths inward from puff sites, indicating deep InsP3-sensitive stores activated at higher concentrations of InsP3. Immunolocalization of InsP3 receptors showed punctate staining throughout a region corresponding to the localization of puffs and subplasmalemmal endoplasmic reticulum. The radial organization of puff sites a few micrometers inward from the plasma membrane may have important consequences for activation of calcium-dependent ion channels and capacitative calcium influx. However, on the macroscopic (hundreds of micrometers) scale of global calcium waves, release can be considered to occur primarily within a thin, essentially two-dimensional subplasmalemmal shell." @default.
• W2080291012 created "2016-06-24" @default.
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• W2080291012 date "1999-02-01" @default.
• W2080291012 modified "2023-10-18" @default.
• W2080291012 title "Radial Localization of Inositol 1,4,5-Trisphosphate–sensitive Ca2+ Release Sites in <i>Xenopus</i> Oocytes Resolved by Axial Confocal Linescan Imaging" @default.
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• W2080291012 doi "https://doi.org/10.1085/jgp.113.2.199" @default.
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