FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080295066> ?p ?o ?g. }

• W2080295066 endingPage "345" @default.
• W2080295066 startingPage "334" @default.
• W2080295066 abstract "Wfs1-deficient mice were generated by disrupting the 8th exon of Wfs1 gene. Reproduction rates of homozygous Wfs1-deficient mice were slightly below the expected values, they displayed intolerance to glucose and overall lower body weight. The present behavioural study was performed in female Wfs1-deficient mice due to their milder metabolic disturbances. Non-fasting blood glucose levels did not differ between homozygous Wfs1-deficient mice and wild-type littermates. While there was no difference in baseline plasma corticosterone, exposure to stress induced a nearly three-fold elevation of corticosterone in Wfs1-deficient mice in relation to wild-type littermates. Wfs1-deficient mice did not display obvious shortcomings in sensory and motor functioning as exemplified by intact responses in conditioned learning paradigms and rota-rod test. Locomotor activity of Wfs1-deficient mice was significantly lower only in brightly lit environment. Short-term isolation had a significant anxiogenic-like effect on the behaviour of Wfs1-deficient mice in dark/light exploration test. Lower exploratory activity of Wfs1-deficient mice in the plus-maze was antagonised by pre-treatment with diazepam (1 mg/kg), a GABA(A) receptor agonist. Wfs1-deficient mice displayed increased anxiety-like behaviour in hyponeophagia test. The locomotor stimulatory effects of amphetamine (2.5-7.5 mg/kg) and apomorphine (3 mg/kg) were significantly attenuated and facilitated, respectively, in Wfs1-deficient mice. There were no differences between Wfs1-deficient mice and wild-types in forced swimming behaviour and conditioned fear responses. Subtle impairments in reversal learning were apparent in Wfs1-deficient mice in the Morris water maze. Altogether, the present study demonstrates impaired behavioural adaptation of Wfs1-deficient mice in stress-inducing situations. It is likely that Wfs1 protein plays a major role in the behavioural adaptation mechanisms to novel and stressful environments." @default.
• W2080295066 created "2016-06-24" @default.
• W2080295066 creator A5012132429 @default.
• W2080295066 creator A5017693223 @default.
• W2080295066 creator A5032022835 @default.
• W2080295066 creator A5032406174 @default.
• W2080295066 creator A5037656140 @default.
• W2080295066 creator A5041706282 @default.
• W2080295066 creator A5048622515 @default.
• W2080295066 creator A5071020080 @default.
• W2080295066 creator A5072489475 @default.
• W2080295066 creator A5073760742 @default.
• W2080295066 date "2009-03-01" @default.
• W2080295066 modified "2023-09-29" @default.
• W2080295066 title "Wfs1-deficient mice display impaired behavioural adaptation in stressful environment" @default.
• W2080295066 cites W1540225236 @default.
• W2080295066 cites W1663689753 @default.
• W2080295066 cites W1964290543 @default.
• W2080295066 cites W1966173885 @default.
• W2080295066 cites W1969018070 @default.
• W2080295066 cites W1970248239 @default.
• W2080295066 cites W1975301556 @default.
• W2080295066 cites W1977313929 @default.
• W2080295066 cites W1978310063 @default.
• W2080295066 cites W1989416066 @default.
• W2080295066 cites W1993850349 @default.
• W2080295066 cites W1995041255 @default.
• W2080295066 cites W2004213733 @default.
• W2080295066 cites W2005111389 @default.
• W2080295066 cites W2010547854 @default.
• W2080295066 cites W2013082402 @default.
• W2080295066 cites W2020184819 @default.
• W2080295066 cites W2027046208 @default.
• W2080295066 cites W2028466989 @default.
• W2080295066 cites W2032058764 @default.
• W2080295066 cites W2035155106 @default.
• W2080295066 cites W2041561931 @default.
• W2080295066 cites W2048172511 @default.
• W2080295066 cites W2061815457 @default.
• W2080295066 cites W2063750361 @default.
• W2080295066 cites W2064315281 @default.
• W2080295066 cites W2068699946 @default.
• W2080295066 cites W2073291608 @default.
• W2080295066 cites W2074089037 @default.
• W2080295066 cites W2074245141 @default.
• W2080295066 cites W2075278392 @default.
• W2080295066 cites W2075951825 @default.
• W2080295066 cites W2076664305 @default.
• W2080295066 cites W2076695658 @default.
• W2080295066 cites W2082576633 @default.
• W2080295066 cites W2088620464 @default.
• W2080295066 cites W2091749707 @default.
• W2080295066 cites W2097535113 @default.
• W2080295066 cites W2099907055 @default.
• W2080295066 cites W2110064753 @default.
• W2080295066 cites W2111205934 @default.
• W2080295066 cites W2115132834 @default.
• W2080295066 cites W2123491442 @default.
• W2080295066 cites W2126793458 @default.
• W2080295066 cites W2131167630 @default.
• W2080295066 cites W2143069340 @default.
• W2080295066 cites W2145183163 @default.
• W2080295066 cites W2149823377 @default.
• W2080295066 cites W2151575431 @default.
• W2080295066 cites W2162605750 @default.
• W2080295066 cites W2165692873 @default.
• W2080295066 cites W2267368291 @default.
• W2080295066 cites W4236781151 @default.
• W2080295066 doi "https://doi.org/10.1016/j.bbr.2008.11.007" @default.
• W2080295066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19041897" @default.
• W2080295066 hasPublicationYear "2009" @default.
• W2080295066 type Work @default.
• W2080295066 sameAs 2080295066 @default.
• W2080295066 citedByCount "68" @default.
• W2080295066 countsByYear W20802950662012 @default.
• W2080295066 countsByYear W20802950662013 @default.
• W2080295066 countsByYear W20802950662014 @default.
• W2080295066 countsByYear W20802950662015 @default.
• W2080295066 countsByYear W20802950662016 @default.
• W2080295066 countsByYear W20802950662017 @default.
• W2080295066 countsByYear W20802950662018 @default.
• W2080295066 countsByYear W20802950662019 @default.
• W2080295066 countsByYear W20802950662020 @default.
• W2080295066 countsByYear W20802950662021 @default.
• W2080295066 countsByYear W20802950662022 @default.
• W2080295066 countsByYear W20802950662023 @default.
• W2080295066 crossrefType "journal-article" @default.
• W2080295066 hasAuthorship W2080295066A5012132429 @default.
• W2080295066 hasAuthorship W2080295066A5017693223 @default.
• W2080295066 hasAuthorship W2080295066A5032022835 @default.
• W2080295066 hasAuthorship W2080295066A5032406174 @default.
• W2080295066 hasAuthorship W2080295066A5037656140 @default.
• W2080295066 hasAuthorship W2080295066A5041706282 @default.
• W2080295066 hasAuthorship W2080295066A5048622515 @default.
• W2080295066 hasAuthorship W2080295066A5071020080 @default.
• W2080295066 hasAuthorship W2080295066A5072489475 @default.
• W2080295066 hasAuthorship W2080295066A5073760742 @default.
• W2080295066 hasConcept C126322002 @default.

• next