FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080304317> ?p ?o ?g. }

• W2080304317 endingPage "154" @default.
• W2080304317 startingPage "144" @default.
• W2080304317 abstract "LC11-RNase H1 is a Sulfolobus tokodaii RNase H1 (Sto-RNase H1) homologue isolated by metagenomic approach. In this study, the crystal structure of LC11-RNase H1 in complex with an RNA/DNA substrate was determined. Unlike Bacillus halodurans RNase H1 without hybrid binding domain (HBD) (Bh-RNase HC) and human RNase H1 without HBD (Hs-RNase HC), LC11-RNase H1 interacts with four non-consecutive 2′-OH groups of the RNA strand. The lack of interactions with four consecutive 2′-OH groups leads to a dramatic decrease in the ability of LC11-RNase H1 to cleave the DNA–RNA–DNA/DNA substrate containing four ribonucleotides as compared to those to cleave the substrates containing five and six ribonucleotides. The interaction of LC11-RNase H1 with the DNA strand is also different from those of Bh-RNase HC and Hs-RNase HC. Beside the common phosphate-binding pocket, LC11-RNase H1 has a unique DNA-binding channel. Furthermore, the active-site residues of LC11-RNase H1 are located farther away from the scissile phosphate group than those of Bh-RNase HC and Hs-RNase HC. Modeling of Sto-RNase H1 in complex with the 14 bp RNA/DNA substrate, together with the structure-based mutational analyses, suggest that the ability of Sto-RNase H1 to cleave double-stranded RNA is dependent on the local conformation of the basic residues located at the DNA binding site." @default.
• W2080304317 created "2016-06-24" @default.
• W2080304317 creator A5056636530 @default.
• W2080304317 creator A5064043466 @default.
• W2080304317 creator A5066897224 @default.
• W2080304317 creator A5078202449 @default.
• W2080304317 creator A5081978092 @default.
• W2080304317 creator A5083232565 @default.
• W2080304317 date "2013-05-01" @default.
• W2080304317 modified "2023-10-14" @default.
• W2080304317 title "Crystal structure of metagenome-derived LC11-RNase H1 in complex with RNA/DNA hybrid" @default.
• W2080304317 cites W1525911572 @default.
• W2080304317 cites W1539796472 @default.
• W2080304317 cites W1557728494 @default.
• W2080304317 cites W1587916613 @default.
• W2080304317 cites W1633146128 @default.
• W2080304317 cites W1689939877 @default.
• W2080304317 cites W1964227936 @default.
• W2080304317 cites W1967154926 @default.
• W2080304317 cites W1969672293 @default.
• W2080304317 cites W1970184264 @default.
• W2080304317 cites W1970590693 @default.
• W2080304317 cites W1976888391 @default.
• W2080304317 cites W1997327174 @default.
• W2080304317 cites W2009443607 @default.
• W2080304317 cites W2012335381 @default.
• W2080304317 cites W2037580974 @default.
• W2080304317 cites W2038840577 @default.
• W2080304317 cites W2038853740 @default.
• W2080304317 cites W2061644680 @default.
• W2080304317 cites W2063558587 @default.
• W2080304317 cites W2073074255 @default.
• W2080304317 cites W2078652488 @default.
• W2080304317 cites W2091760726 @default.
• W2080304317 cites W2098473889 @default.
• W2080304317 cites W2100837269 @default.
• W2080304317 cites W2104292740 @default.
• W2080304317 cites W2120967544 @default.
• W2080304317 cites W2122020699 @default.
• W2080304317 cites W2126385000 @default.
• W2080304317 cites W2134093918 @default.
• W2080304317 cites W2137633625 @default.
• W2080304317 cites W2143406467 @default.
• W2080304317 cites W2144029907 @default.
• W2080304317 cites W2144081223 @default.
• W2080304317 cites W2146230109 @default.
• W2080304317 cites W2157435389 @default.
• W2080304317 cites W2159579808 @default.
• W2080304317 doi "https://doi.org/10.1016/j.jsb.2013.02.018" @default.
• W2080304317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23500886" @default.
• W2080304317 hasPublicationYear "2013" @default.
• W2080304317 type Work @default.
• W2080304317 sameAs 2080304317 @default.
• W2080304317 citedByCount "7" @default.
• W2080304317 countsByYear W20803043172013 @default.
• W2080304317 countsByYear W20803043172014 @default.
• W2080304317 countsByYear W20803043172017 @default.
• W2080304317 countsByYear W20803043172019 @default.
• W2080304317 crossrefType "journal-article" @default.
• W2080304317 hasAuthorship W2080304317A5056636530 @default.
• W2080304317 hasAuthorship W2080304317A5064043466 @default.
• W2080304317 hasAuthorship W2080304317A5066897224 @default.
• W2080304317 hasAuthorship W2080304317A5078202449 @default.
• W2080304317 hasAuthorship W2080304317A5081978092 @default.
• W2080304317 hasAuthorship W2080304317A5083232565 @default.
• W2080304317 hasConcept C104317684 @default.
• W2080304317 hasConcept C10879258 @default.
• W2080304317 hasConcept C153911025 @default.
• W2080304317 hasConcept C188528350 @default.
• W2080304317 hasConcept C19014433 @default.
• W2080304317 hasConcept C195500695 @default.
• W2080304317 hasConcept C552990157 @default.
• W2080304317 hasConcept C55493867 @default.
• W2080304317 hasConcept C67705224 @default.
• W2080304317 hasConcept C69766542 @default.
• W2080304317 hasConcept C86803240 @default.
• W2080304317 hasConceptScore W2080304317C104317684 @default.
• W2080304317 hasConceptScore W2080304317C10879258 @default.
• W2080304317 hasConceptScore W2080304317C153911025 @default.
• W2080304317 hasConceptScore W2080304317C188528350 @default.
• W2080304317 hasConceptScore W2080304317C19014433 @default.
• W2080304317 hasConceptScore W2080304317C195500695 @default.
• W2080304317 hasConceptScore W2080304317C552990157 @default.
• W2080304317 hasConceptScore W2080304317C55493867 @default.
• W2080304317 hasConceptScore W2080304317C67705224 @default.
• W2080304317 hasConceptScore W2080304317C69766542 @default.
• W2080304317 hasConceptScore W2080304317C86803240 @default.
• W2080304317 hasFunder F4320320912 @default.
• W2080304317 hasFunder F4320322111 @default.
• W2080304317 hasIssue "2" @default.
• W2080304317 hasLocation W20803043171 @default.
• W2080304317 hasLocation W20803043172 @default.
• W2080304317 hasOpenAccess W2080304317 @default.
• W2080304317 hasPrimaryLocation W20803043171 @default.
• W2080304317 hasRelatedWork W1750017366 @default.
• W2080304317 hasRelatedWork W2003479409 @default.
• W2080304317 hasRelatedWork W2049770615 @default.
• W2080304317 hasRelatedWork W2059234972 @default.

• next