Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080305329> ?p ?o ?g. }
- W2080305329 endingPage "13883" @default.
- W2080305329 startingPage "13878" @default.
- W2080305329 abstract "Liver X receptors (LXRalpha and -beta) are nuclear receptors abundant in the liver where they are regulators of lipid homeostasis. Both LXRs are also expressed in the brain, but their roles in this tissue remain to be clarified. We examined the brains of mice in which the genes of both LXRalpha and -beta have been disrupted and found several severe abnormalities. One of the most striking features is that the lateral ventricles are closed and lined with lipid-laden cells. In addition, there are enlarged brain blood vessels, especially in the pars reticularis of the substantia nigra and in the globus pallidus. Other features of the brains are excessive lipid deposits, proliferation of astrocytes, loss of neurons, and disorganized myelin sheaths. Electron micrographs revealed that, as mice aged, lipid vacuoles accumulated in astrocytes surrounding blood vessels. Comparison of mRNA profiles in LXR knockout mice and wild-type littermates showed that expression of several LXR target genes involved in cholesterol efflux from astrocytes was reduced. These findings show that LXRs have an important function in lipid homeostasis in the brain, and that loss of these receptors results in neurodegenerative diseases. Further characterization of the role of LXRs in the brain could lead to new insights into the etiology and treatment of some neurodegenerative disorders." @default.
- W2080305329 created "2016-06-24" @default.
- W2080305329 creator A5019030826 @default.
- W2080305329 creator A5022167855 @default.
- W2080305329 creator A5036193907 @default.
- W2080305329 creator A5039135526 @default.
- W2080305329 creator A5044341883 @default.
- W2080305329 creator A5050487837 @default.
- W2080305329 date "2002-10-04" @default.
- W2080305329 modified "2023-10-10" @default.
- W2080305329 title "Liver X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration" @default.
- W2080305329 cites W1570388980 @default.
- W2080305329 cites W1962935964 @default.
- W2080305329 cites W1967286688 @default.
- W2080305329 cites W1974988155 @default.
- W2080305329 cites W1991624718 @default.
- W2080305329 cites W1993629125 @default.
- W2080305329 cites W1996168740 @default.
- W2080305329 cites W2001332055 @default.
- W2080305329 cites W2002672592 @default.
- W2080305329 cites W2003742510 @default.
- W2080305329 cites W2003798182 @default.
- W2080305329 cites W2003840075 @default.
- W2080305329 cites W2004168108 @default.
- W2080305329 cites W2009139369 @default.
- W2080305329 cites W2014020803 @default.
- W2080305329 cites W2022906574 @default.
- W2080305329 cites W2023938799 @default.
- W2080305329 cites W2024851295 @default.
- W2080305329 cites W2037254183 @default.
- W2080305329 cites W2039664177 @default.
- W2080305329 cites W2040417680 @default.
- W2080305329 cites W2042787593 @default.
- W2080305329 cites W2047613132 @default.
- W2080305329 cites W2057365200 @default.
- W2080305329 cites W2066125981 @default.
- W2080305329 cites W2067064610 @default.
- W2080305329 cites W2072992430 @default.
- W2080305329 cites W2073748140 @default.
- W2080305329 cites W2081732968 @default.
- W2080305329 cites W2085909854 @default.
- W2080305329 cites W2086317930 @default.
- W2080305329 cites W2116824509 @default.
- W2080305329 cites W2118867675 @default.
- W2080305329 cites W2122506320 @default.
- W2080305329 cites W2135007868 @default.
- W2080305329 cites W2138659411 @default.
- W2080305329 cites W2143795852 @default.
- W2080305329 cites W2149457192 @default.
- W2080305329 cites W2153673003 @default.
- W2080305329 cites W2159464926 @default.
- W2080305329 cites W2161002325 @default.
- W2080305329 cites W2170079782 @default.
- W2080305329 cites W2226116716 @default.
- W2080305329 cites W2367049629 @default.
- W2080305329 cites W2409121684 @default.
- W2080305329 doi "https://doi.org/10.1073/pnas.172510899" @default.
- W2080305329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/129791" @default.
- W2080305329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12368482" @default.
- W2080305329 hasPublicationYear "2002" @default.
- W2080305329 type Work @default.
- W2080305329 sameAs 2080305329 @default.
- W2080305329 citedByCount "250" @default.
- W2080305329 countsByYear W20803053292012 @default.
- W2080305329 countsByYear W20803053292013 @default.
- W2080305329 countsByYear W20803053292014 @default.
- W2080305329 countsByYear W20803053292015 @default.
- W2080305329 countsByYear W20803053292016 @default.
- W2080305329 countsByYear W20803053292017 @default.
- W2080305329 countsByYear W20803053292018 @default.
- W2080305329 countsByYear W20803053292019 @default.
- W2080305329 countsByYear W20803053292020 @default.
- W2080305329 countsByYear W20803053292021 @default.
- W2080305329 countsByYear W20803053292022 @default.
- W2080305329 countsByYear W20803053292023 @default.
- W2080305329 crossrefType "journal-article" @default.
- W2080305329 hasAuthorship W2080305329A5019030826 @default.
- W2080305329 hasAuthorship W2080305329A5022167855 @default.
- W2080305329 hasAuthorship W2080305329A5036193907 @default.
- W2080305329 hasAuthorship W2080305329A5039135526 @default.
- W2080305329 hasAuthorship W2080305329A5044341883 @default.
- W2080305329 hasAuthorship W2080305329A5050487837 @default.
- W2080305329 hasBestOaLocation W20803053291 @default.
- W2080305329 hasConcept C104317684 @default.
- W2080305329 hasConcept C126322002 @default.
- W2080305329 hasConcept C134018914 @default.
- W2080305329 hasConcept C137183658 @default.
- W2080305329 hasConcept C167400880 @default.
- W2080305329 hasConcept C170493617 @default.
- W2080305329 hasConcept C2776773494 @default.
- W2080305329 hasConcept C2778187257 @default.
- W2080305329 hasConcept C2780278869 @default.
- W2080305329 hasConcept C2780938664 @default.
- W2080305329 hasConcept C4733338 @default.
- W2080305329 hasConcept C513476851 @default.
- W2080305329 hasConcept C529278444 @default.
- W2080305329 hasConcept C55493867 @default.
- W2080305329 hasConcept C63645605 @default.