Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080308068> ?p ?o ?g. }
- W2080308068 endingPage "47" @default.
- W2080308068 startingPage "27" @default.
- W2080308068 abstract "Since the discovery of the Ca(2+) mobilizing effects of the pyridine nucleotide metabolite, nicotinic acid adenine dinucleotide phosphate (NAADP), this molecule has been demonstrated to function as a Ca(2+) mobilizing intracellular messenger in a wide range of cell types. In this review, I will briefly summarize the distinct principles behind NAADP-mediated Ca(2+) signalling before going on to outline the role of this messenger in the physiology of specific cell types. Central to the discussion here is the finding that NAADP principally mobilizes Ca(2+) from acidic organelles such as lysosomes and it is this property that allows NAADP to play a unique role in intracellular Ca(2+) signalling. Lysosomes and related organelles are small Ca(2+) stores but importantly may also initiate a two-way dialogue with other Ca(2+) storage organelles to amplify Ca(2+) release, and may be strategically localized to influence localized Ca(2+) signalling microdomains. The study of NAADP signalling has created a new and fruitful focus on the lysosome and endolysosomal system as major players in calcium signalling and pathophysiology." @default.
- W2080308068 created "2016-06-24" @default.
- W2080308068 creator A5026573711 @default.
- W2080308068 date "2015-07-01" @default.
- W2080308068 modified "2023-09-25" @default.
- W2080308068 title "A primer of NAADP-mediated Ca2+ signalling: From sea urchin eggs to mammalian cells" @default.
- W2080308068 cites W1488216507 @default.
- W2080308068 cites W1490898621 @default.
- W2080308068 cites W1498402398 @default.
- W2080308068 cites W1528977425 @default.
- W2080308068 cites W1532593591 @default.
- W2080308068 cites W1552208437 @default.
- W2080308068 cites W1556555719 @default.
- W2080308068 cites W1579421676 @default.
- W2080308068 cites W1615545200 @default.
- W2080308068 cites W1716638576 @default.
- W2080308068 cites W1782667879 @default.
- W2080308068 cites W1816002577 @default.
- W2080308068 cites W1853732393 @default.
- W2080308068 cites W1963403501 @default.
- W2080308068 cites W1963869670 @default.
- W2080308068 cites W1964384026 @default.
- W2080308068 cites W1965590635 @default.
- W2080308068 cites W1965778360 @default.
- W2080308068 cites W1965966720 @default.
- W2080308068 cites W1966879697 @default.
- W2080308068 cites W1967329828 @default.
- W2080308068 cites W1967940275 @default.
- W2080308068 cites W1968004900 @default.
- W2080308068 cites W1968966344 @default.
- W2080308068 cites W1969637387 @default.
- W2080308068 cites W1970997423 @default.
- W2080308068 cites W1972080672 @default.
- W2080308068 cites W1972826154 @default.
- W2080308068 cites W1973219173 @default.
- W2080308068 cites W1973391847 @default.
- W2080308068 cites W1973861460 @default.
- W2080308068 cites W1975832881 @default.
- W2080308068 cites W1975992025 @default.
- W2080308068 cites W1976074221 @default.
- W2080308068 cites W1976269779 @default.
- W2080308068 cites W1977746407 @default.
- W2080308068 cites W1978678832 @default.
- W2080308068 cites W1979174952 @default.
- W2080308068 cites W1979482249 @default.
- W2080308068 cites W1980828399 @default.
- W2080308068 cites W1982501218 @default.
- W2080308068 cites W1982909265 @default.
- W2080308068 cites W1983181941 @default.
- W2080308068 cites W1984638411 @default.
- W2080308068 cites W1984983689 @default.
- W2080308068 cites W1985313695 @default.
- W2080308068 cites W1987064331 @default.
- W2080308068 cites W1987613834 @default.
- W2080308068 cites W1987769185 @default.
- W2080308068 cites W1988191467 @default.
- W2080308068 cites W1988252217 @default.
- W2080308068 cites W1989779273 @default.
- W2080308068 cites W1990708583 @default.
- W2080308068 cites W1993401680 @default.
- W2080308068 cites W1993480617 @default.
- W2080308068 cites W1993604643 @default.
- W2080308068 cites W1994966986 @default.
- W2080308068 cites W1995873775 @default.
- W2080308068 cites W1997119596 @default.
- W2080308068 cites W1997223430 @default.
- W2080308068 cites W1997778815 @default.
- W2080308068 cites W1998735059 @default.
- W2080308068 cites W2000845667 @default.
- W2080308068 cites W2001695130 @default.
- W2080308068 cites W2002194891 @default.
- W2080308068 cites W2002557150 @default.
- W2080308068 cites W2003787957 @default.
- W2080308068 cites W2004400037 @default.
- W2080308068 cites W2004790978 @default.
- W2080308068 cites W2005169575 @default.
- W2080308068 cites W2005302551 @default.
- W2080308068 cites W2005560465 @default.
- W2080308068 cites W2006190060 @default.
- W2080308068 cites W2007066406 @default.
- W2080308068 cites W2008245136 @default.
- W2080308068 cites W2010998933 @default.
- W2080308068 cites W2011432266 @default.
- W2080308068 cites W2011577446 @default.
- W2080308068 cites W2015318490 @default.
- W2080308068 cites W2016983155 @default.
- W2080308068 cites W2017593971 @default.
- W2080308068 cites W2018745495 @default.
- W2080308068 cites W2019890971 @default.
- W2080308068 cites W2020641905 @default.
- W2080308068 cites W2021327869 @default.
- W2080308068 cites W2025447674 @default.
- W2080308068 cites W2026571586 @default.
- W2080308068 cites W2027539976 @default.
- W2080308068 cites W2029072905 @default.
- W2080308068 cites W2029205502 @default.
- W2080308068 cites W2029279326 @default.
- W2080308068 cites W2030650261 @default.