Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080308097> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2080308097 endingPage "2350" @default.
- W2080308097 startingPage "2347" @default.
- W2080308097 abstract "The major histocompatibility complex (MHC) controls of the outcome of the immune response to T cell-dependent antigens by dictating whether T cell responsiveness will result (MHC-immune response [Ir]genes) or alternatively T cell nonresponsiveness will occur, possibly through the activation of suppressor cells (MHC-immune suppression [Is] genes). In mice, I-A molecules typically restrict antigen-specific helper T cells. In contrast, H-2 I-E molecules have been reported to control nonresponsiveness to a variety of antigens through antigen-specific suppressor cells. In analogy, HLA-DR molecules are the dominant restriction elements for helper T cells in man. This forces the question whether DQ molecules may be involved in controlling nonresponsiveness in man, e.g. through suppression. In one system, T cell nonresponsiveness to Schistosoma japonicum, evidence has been presented supporting this notion. We have now used a second system, Mycobacterium leprae-specific T cell nonresponsiveness, that is typically found in lepromatous leprosy patients. We find positive but limited evidence for a role for HLA-DQ molecules in controlling T cell nonresponsiveness to M. leprae of the 22 nonresponder patients tested, 4 showed a proliferative T cell response to M. leprae after the addition of DQ- but not DR-specific mAb to the cell cultures. In one of the four BCG nonresponders, anti-DQ mAb had a similar effect." @default.
- W2080308097 created "2016-06-24" @default.
- W2080308097 creator A5003746748 @default.
- W2080308097 creator A5004201118 @default.
- W2080308097 creator A5052639161 @default.
- W2080308097 creator A5054335064 @default.
- W2080308097 creator A5085127863 @default.
- W2080308097 date "1990-10-01" @default.
- W2080308097 modified "2023-10-02" @default.
- W2080308097 title "HLA-DQ molecules and the control ofMycobacterium leprae-specific T cell nonresponsiveness in lepromatous leprosy patients" @default.
- W2080308097 cites W1982312374 @default.
- W2080308097 cites W1999726159 @default.
- W2080308097 cites W2007461616 @default.
- W2080308097 cites W2011827552 @default.
- W2080308097 cites W2018381639 @default.
- W2080308097 cites W2033051054 @default.
- W2080308097 cites W2053686485 @default.
- W2080308097 cites W2077484968 @default.
- W2080308097 cites W2087361717 @default.
- W2080308097 cites W2087532443 @default.
- W2080308097 cites W2111079695 @default.
- W2080308097 cites W2146805638 @default.
- W2080308097 cites W2162608883 @default.
- W2080308097 cites W2176716563 @default.
- W2080308097 cites W2323970094 @default.
- W2080308097 cites W4243733665 @default.
- W2080308097 doi "https://doi.org/10.1002/eji.1830201027" @default.
- W2080308097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1700754" @default.
- W2080308097 hasPublicationYear "1990" @default.
- W2080308097 type Work @default.
- W2080308097 sameAs 2080308097 @default.
- W2080308097 citedByCount "25" @default.
- W2080308097 countsByYear W20803080972014 @default.
- W2080308097 countsByYear W20803080972016 @default.
- W2080308097 countsByYear W20803080972018 @default.
- W2080308097 crossrefType "journal-article" @default.
- W2080308097 hasAuthorship W2080308097A5003746748 @default.
- W2080308097 hasAuthorship W2080308097A5004201118 @default.
- W2080308097 hasAuthorship W2080308097A5052639161 @default.
- W2080308097 hasAuthorship W2080308097A5054335064 @default.
- W2080308097 hasAuthorship W2080308097A5085127863 @default.
- W2080308097 hasConcept C147483822 @default.
- W2080308097 hasConcept C203014093 @default.
- W2080308097 hasConcept C207936829 @default.
- W2080308097 hasConcept C2776090121 @default.
- W2080308097 hasConcept C2779823659 @default.
- W2080308097 hasConcept C2780695269 @default.
- W2080308097 hasConcept C67662055 @default.
- W2080308097 hasConcept C86803240 @default.
- W2080308097 hasConcept C8891405 @default.
- W2080308097 hasConceptScore W2080308097C147483822 @default.
- W2080308097 hasConceptScore W2080308097C203014093 @default.
- W2080308097 hasConceptScore W2080308097C207936829 @default.
- W2080308097 hasConceptScore W2080308097C2776090121 @default.
- W2080308097 hasConceptScore W2080308097C2779823659 @default.
- W2080308097 hasConceptScore W2080308097C2780695269 @default.
- W2080308097 hasConceptScore W2080308097C67662055 @default.
- W2080308097 hasConceptScore W2080308097C86803240 @default.
- W2080308097 hasConceptScore W2080308097C8891405 @default.
- W2080308097 hasIssue "10" @default.
- W2080308097 hasLocation W20803080971 @default.
- W2080308097 hasLocation W20803080972 @default.
- W2080308097 hasOpenAccess W2080308097 @default.
- W2080308097 hasPrimaryLocation W20803080971 @default.
- W2080308097 hasRelatedWork W2000941383 @default.
- W2080308097 hasRelatedWork W2031508422 @default.
- W2080308097 hasRelatedWork W2072058089 @default.
- W2080308097 hasRelatedWork W2080308097 @default.
- W2080308097 hasRelatedWork W2220102944 @default.
- W2080308097 hasRelatedWork W2244947588 @default.
- W2080308097 hasRelatedWork W2409441623 @default.
- W2080308097 hasRelatedWork W2418654200 @default.
- W2080308097 hasRelatedWork W2591098767 @default.
- W2080308097 hasRelatedWork W4210976760 @default.
- W2080308097 hasVolume "20" @default.
- W2080308097 isParatext "false" @default.
- W2080308097 isRetracted "false" @default.
- W2080308097 magId "2080308097" @default.
- W2080308097 workType "article" @default.