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- W2080309266 abstract "0 VER THE PAST 20 years, advancements have occurred in our understanding of the pathogenesis of acute myeloid leukemia (AML) and our ability to optimize treatment of this disease. A patient presenting today with de novo AML can be given a more accurate prognosis than would have been possible two decades ago and, for some, the outlook is now brighter than it would have been 20, or even 10 years ago. These changes have come about through realization of the importance of cytogenetics and other biologic factors in the outcome of treatment, through recognition of the role of dose intensification in treatment, and through improvements in supportive care that have enabled safer delivery of very intensive chemotherapy regimens. Overall survival among patients entered into clinical trials has steadily increased. However, this improvement is not distributed evenly across prognostic groups; the benefits have been greater among patients with good-risk disease than in those with poor-risk disease. AML is predominantly a disease of the elderly, with more than 50% of cases arising in adults aged over 60 years. Older age remains a poor-prognosis factor in AML. Among patients aged 15 to 59 years who entered clinical trials in the mid to late 199Os, more than 50% are still alive after 3 100" @default.
- W2080309266 created "2016-06-24" @default.
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- W2080309266 date "2001-07-01" @default.
- W2080309266 modified "2023-09-27" @default.
- W2080309266 title "Introduction: Modern management of acute myeloid leukemia" @default.
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- W2080309266 doi "https://doi.org/10.1016/s0037-1963(01)90149-0" @default.
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