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- W2080311309 abstract "Summary Background Matrix metalloproteinase‐9 (MMP‐9) is an important enzyme responsible for airway remodelling. Monocytes/macrophages have a cysteinyl leukotriene 1 (cysLT1) receptor, but its function is poorly understood. Objective To elucidate the function of the cysLT1 receptor of human monocytes/macrophages in MMP‐9 production. Methods We examined the effect of cysLTs (LTC4, ‐D4 and ‐E4) on TNF‐α‐induced MMP‐9 production in THP‐1 cells, a human monocytic leukaemia cell line and peripheral blood CD14 + monocytes/macrophages. In addition, we examined the effect of pranlukast, a cysLT1 receptor antagonist, on the enhancement of TNF‐α‐induced MMP‐9 production by cysLTs. Results ELISA revealed that LTC4 and ‐D4, but not ‐E4, enhanced TNF‐α‐induced MMP‐9 production in THP‐1 cells and peripheral blood CD14 + monocytes/macrophages. Real‐time polymerase chain reaction demonstrated that LTC4 and ‐D4, but not ‐E4, increased MMP‐9 mRNA expression induced by TNF‐α in THP‐1 cells. Moreover, we demonstrated that pranlukast completely inhibited the enhancement of TNF‐α‐induced MMP‐9 production by LTC4 and ‐D4 in THP‐1 cells and peripheral blood CD14 + monocytes/macrophages. Conclusion LTC4 and ‐D4 enhanced the TNF‐α‐induced MMP‐9 production via binding the cysLT1 receptor in human monocytes/macrophages. Pranlukast inhibited the enhancements by LTC4 and D4." @default.
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- W2080311309 date "2007-04-01" @default.
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- W2080311309 title "Cysteinyl leukotrienes enhance tumour necrosis factor-?-induced matrix metalloproteinase-9 in human monocytes/macrophages" @default.
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- W2080311309 doi "https://doi.org/10.1111/j.1365-2222.2007.02692.x" @default.
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