FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080315961> ?p ?o ?g. }

• W2080315961 abstract "Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CABackground: Thymic Hyperplasia refers to an enlargement of the thymus, while thymomas display significant heterogeneity from morphologic point of view, clinical behaviour, expression of immunohistochemical markers and molecular profiling. Therefore improving our understanding of the molecular biology of thymic disorders represents a key challenge in the treatment of these rare diseases.Methods:The genomic DNA of 93 consecutive patients undergoing total thymectomy at our Institution was extracted from paraffin-embedded tissue.We selected the following SNPs: Hypoxia Inducible Factor-1 alpha (HIF1a: rs2057482T>C, rs1951795A>C, rs2301113C>A, rs10873142C>T, rs11158358G>C, rs12434438G>A, rs11549465C>T, rs11549467G>A), Vascular Endothelial Growth Factor-A (VEGF-A: rs2010963G>C, rs699947A>C), VEGF Receptor 2 (VEGFR-2: rs2305948C>T, rs1870377T>A), VEGFR-3 (rs307826T>C, rs307821C>A), Platelet-Derived Growth Factor-A (PDGFR-A: rs35597368C>T).Gene polymorphisms were determined by Real-Time PCR using TaqMan assays.Results:93 patients were included into the study, 58 females and 35 males.The patients underwent surgery: 43 for thymomas, 14 for thymic carcinomas, 36 for thymic hyperplasia.The frequency of PDGFRa rs35597368T (95.24%) was significantly higher in thymic malignancies if compared with data available for population (86%, p=0.012), thus suggesting that it may represent a risk factor for this type of disease. On the other hand, the frequency of several HIF-1a polymorphisms (rs2057482C, rs11549465C, rs1951795C, rs2301113A, rs10873142T, rs11158358C, rs12434438A) resulted lower in our study than in the general population (p<0.05). In particular, frequencies of HIF1a rs1951795C, rs2301113A, rs12434438A were significantly lower in thymic malignancy than in thymic hyperplasia and moreover these were lower than population, according to available literature data on other types of tumors, suggesting a protective role.Furthermore, VEGFR3 rs307821C polymorphism was higher in thymoma than in thymic carcinoma (79.5% vs 72%, p=0.0371), and therefore it seems to be related to a lower grade of malignancy.Finally, the following factors were significantly correlated with a better overall survival: VEGFR-3 rs307826C, VEGFR-2 rs1870377A, PDGFR-A rs35597368T/C, HIF1a rs2301113C, rs2057482C/T, rs1951795C, rs11158358G/C and rs10873142T/C (p<0.05).Conclusion: To the best of our knowledge this is the largest monocentric study analyzing the angiogenetic variants in thymic hyperplasia and tumors representing a further asset in the definition of high-risk patients after curative resection, also driving the selection of more aggressive adjuvant treatment in this subgroup of patients. The selection tool deriving from this analysis may allow an optimal use of innovative treatment strategies in thymic malignancies including targeted agents such as sunitinib, sorafenib or pazopanib.Citation Format: Rossana Berardi, Silvia Pagliaretta, Alessandro Brunelli, Vittorio Paolucci, Gaia Goteri, Majed Refai, Cecilia Pompili, Agnese Savini, Giulia Marcantognini, Mariangela Torniai, Michela Tiberi, Consuelo Ferrini, Francesca Morgese, Miriam Caramanti, Silvia Rinaldi, Azzurra Onofri, Antonio Zizzi, Paola Mazzanti, Stefano Cascinu. Impact of single-nucleotide polymorphisms (SNPs) on thymic hyperplasia and tumors outcome. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2220. doi:10.1158/1538-7445.AM2014-2220" @default.
• W2080315961 created "2016-06-24" @default.
• W2080315961 creator A5019053015 @default.
• W2080315961 creator A5019195223 @default.
• W2080315961 creator A5038465938 @default.
• W2080315961 creator A5039055427 @default.
• W2080315961 creator A5042028913 @default.
• W2080315961 creator A5049583430 @default.
• W2080315961 creator A5053763899 @default.
• W2080315961 creator A5056208054 @default.
• W2080315961 creator A5058356885 @default.
• W2080315961 creator A5063059411 @default.
• W2080315961 creator A5066862342 @default.
• W2080315961 creator A5072776768 @default.
• W2080315961 creator A5074517752 @default.
• W2080315961 creator A5075790876 @default.
• W2080315961 creator A5084577396 @default.
• W2080315961 creator A5085123299 @default.
• W2080315961 creator A5085311725 @default.
• W2080315961 creator A5088171420 @default.
• W2080315961 creator A5089249448 @default.
• W2080315961 date "2014-09-30" @default.
• W2080315961 modified "2023-09-27" @default.
• W2080315961 title "Abstract 2220: Impact of single-nucleotide polymorphisms (SNPs) on thymic hyperplasia and tumors outcome" @default.
• W2080315961 doi "https://doi.org/10.1158/1538-7445.am2014-2220" @default.
• W2080315961 hasPublicationYear "2014" @default.
• W2080315961 type Work @default.
• W2080315961 sameAs 2080315961 @default.
• W2080315961 citedByCount "0" @default.
• W2080315961 crossrefType "proceedings-article" @default.
• W2080315961 hasAuthorship W2080315961A5019053015 @default.
• W2080315961 hasAuthorship W2080315961A5019195223 @default.
• W2080315961 hasAuthorship W2080315961A5038465938 @default.
• W2080315961 hasAuthorship W2080315961A5039055427 @default.
• W2080315961 hasAuthorship W2080315961A5042028913 @default.
• W2080315961 hasAuthorship W2080315961A5049583430 @default.
• W2080315961 hasAuthorship W2080315961A5053763899 @default.
• W2080315961 hasAuthorship W2080315961A5056208054 @default.
• W2080315961 hasAuthorship W2080315961A5058356885 @default.
• W2080315961 hasAuthorship W2080315961A5063059411 @default.
• W2080315961 hasAuthorship W2080315961A5066862342 @default.
• W2080315961 hasAuthorship W2080315961A5072776768 @default.
• W2080315961 hasAuthorship W2080315961A5074517752 @default.
• W2080315961 hasAuthorship W2080315961A5075790876 @default.
• W2080315961 hasAuthorship W2080315961A5084577396 @default.
• W2080315961 hasAuthorship W2080315961A5085123299 @default.
• W2080315961 hasAuthorship W2080315961A5085311725 @default.
• W2080315961 hasAuthorship W2080315961A5088171420 @default.
• W2080315961 hasAuthorship W2080315961A5089249448 @default.
• W2080315961 hasConcept C104317684 @default.
• W2080315961 hasConcept C126322002 @default.
• W2080315961 hasConcept C135763542 @default.
• W2080315961 hasConcept C142724271 @default.
• W2080315961 hasConcept C143998085 @default.
• W2080315961 hasConcept C153209595 @default.
• W2080315961 hasConcept C167734588 @default.
• W2080315961 hasConcept C16930146 @default.
• W2080315961 hasConcept C2775922572 @default.
• W2080315961 hasConcept C2776349617 @default.
• W2080315961 hasConcept C2777025900 @default.
• W2080315961 hasConcept C2777562237 @default.
• W2080315961 hasConcept C2778105408 @default.
• W2080315961 hasConcept C2779159893 @default.
• W2080315961 hasConcept C2779615886 @default.
• W2080315961 hasConcept C2780394083 @default.
• W2080315961 hasConcept C2908647359 @default.
• W2080315961 hasConcept C31194975 @default.
• W2080315961 hasConcept C37307934 @default.
• W2080315961 hasConcept C502942594 @default.
• W2080315961 hasConcept C54355233 @default.
• W2080315961 hasConcept C71924100 @default.
• W2080315961 hasConcept C86803240 @default.
• W2080315961 hasConcept C99454951 @default.
• W2080315961 hasConceptScore W2080315961C104317684 @default.
• W2080315961 hasConceptScore W2080315961C126322002 @default.
• W2080315961 hasConceptScore W2080315961C135763542 @default.
• W2080315961 hasConceptScore W2080315961C142724271 @default.
• W2080315961 hasConceptScore W2080315961C143998085 @default.
• W2080315961 hasConceptScore W2080315961C153209595 @default.
• W2080315961 hasConceptScore W2080315961C167734588 @default.
• W2080315961 hasConceptScore W2080315961C16930146 @default.
• W2080315961 hasConceptScore W2080315961C2775922572 @default.
• W2080315961 hasConceptScore W2080315961C2776349617 @default.
• W2080315961 hasConceptScore W2080315961C2777025900 @default.
• W2080315961 hasConceptScore W2080315961C2777562237 @default.
• W2080315961 hasConceptScore W2080315961C2778105408 @default.
• W2080315961 hasConceptScore W2080315961C2779159893 @default.
• W2080315961 hasConceptScore W2080315961C2779615886 @default.
• W2080315961 hasConceptScore W2080315961C2780394083 @default.
• W2080315961 hasConceptScore W2080315961C2908647359 @default.
• W2080315961 hasConceptScore W2080315961C31194975 @default.
• W2080315961 hasConceptScore W2080315961C37307934 @default.
• W2080315961 hasConceptScore W2080315961C502942594 @default.
• W2080315961 hasConceptScore W2080315961C54355233 @default.
• W2080315961 hasConceptScore W2080315961C71924100 @default.
• W2080315961 hasConceptScore W2080315961C86803240 @default.
• W2080315961 hasConceptScore W2080315961C99454951 @default.
• W2080315961 hasLocation W20803159611 @default.
• W2080315961 hasOpenAccess W2080315961 @default.
• W2080315961 hasPrimaryLocation W20803159611 @default.

• next