Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080321337> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2080321337 endingPage "20361" @default.
- W2080321337 startingPage "20360" @default.
- W2080321337 abstract "Pseudomonas aeruginosa is a prevalent nosocomial pathogen (1) and a threat in neonatal and intensive care units, causing deadly infections in ventilator-associated pneumonia or immunosuppressed patients. P. aeruginosa strains causing these infections are frequently multiresistant, and treatment is a nightmare for clinicians (2). P. aeruginosa colonizing the lungs of cystic fibrosis patients cannot be eradicated even after intensive antibiotic therapy. Combinatorial therapies make use of β-lactams, colistin, fluoroquinolone, or aminoglycosides, but resistance to these drugs keeps emerging at high rate, except for colistin. The acquisition of resistance happens via mutations or acquisition of new functions by horizontal gene transfer. The downside for bacteria acquiring resistance is a pay back in fitness cost. Antibiotics target vital cell functions, such as protein synthesis, DNA supercoiling, or integrity of the cell envelope, and compensatory mutations may result in these features not being reliable (3). This is good news and suggests that once the selective pressure of antibiotic treatment ceased, the resistant strains could be outcompeted by strains that are not resistant but fitter, which will be a stumbling block to the spread of multiresistant organisms. However, the work by Skurnik et al. in PNAS (4) demonstrates that a gain of in vivo fitness by P. aeruginosa is due to the lack of the outer membrane protein OprD, and this event correlates acquisition of carbapenem resistance." @default.
- W2080321337 created "2016-06-24" @default.
- W2080321337 creator A5031492621 @default.
- W2080321337 date "2013-11-27" @default.
- W2080321337 modified "2023-09-26" @default.
- W2080321337 title "Fit and resistant is a worst case scenario with bacterial pathogens" @default.
- W2080321337 cites W1751253656 @default.
- W2080321337 cites W1956021930 @default.
- W2080321337 cites W1963890672 @default.
- W2080321337 cites W1979152503 @default.
- W2080321337 cites W2040011481 @default.
- W2080321337 cites W2044584162 @default.
- W2080321337 cites W2067906280 @default.
- W2080321337 cites W2069107501 @default.
- W2080321337 cites W2073556554 @default.
- W2080321337 cites W2126206925 @default.
- W2080321337 cites W2128433990 @default.
- W2080321337 cites W2148054572 @default.
- W2080321337 cites W2157666459 @default.
- W2080321337 cites W2161201184 @default.
- W2080321337 doi "https://doi.org/10.1073/pnas.1319862110" @default.
- W2080321337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3870691" @default.
- W2080321337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24284168" @default.
- W2080321337 hasPublicationYear "2013" @default.
- W2080321337 type Work @default.
- W2080321337 sameAs 2080321337 @default.
- W2080321337 citedByCount "2" @default.
- W2080321337 countsByYear W20803213372013 @default.
- W2080321337 countsByYear W20803213372021 @default.
- W2080321337 crossrefType "journal-article" @default.
- W2080321337 hasAuthorship W2080321337A5031492621 @default.
- W2080321337 hasBestOaLocation W20803213371 @default.
- W2080321337 hasConcept C41008148 @default.
- W2080321337 hasConcept C70721500 @default.
- W2080321337 hasConcept C86803240 @default.
- W2080321337 hasConcept C89423630 @default.
- W2080321337 hasConceptScore W2080321337C41008148 @default.
- W2080321337 hasConceptScore W2080321337C70721500 @default.
- W2080321337 hasConceptScore W2080321337C86803240 @default.
- W2080321337 hasConceptScore W2080321337C89423630 @default.
- W2080321337 hasIssue "51" @default.
- W2080321337 hasLocation W20803213371 @default.
- W2080321337 hasLocation W20803213372 @default.
- W2080321337 hasLocation W20803213373 @default.
- W2080321337 hasLocation W20803213374 @default.
- W2080321337 hasOpenAccess W2080321337 @default.
- W2080321337 hasPrimaryLocation W20803213371 @default.
- W2080321337 hasRelatedWork W1641042124 @default.
- W2080321337 hasRelatedWork W1990804418 @default.
- W2080321337 hasRelatedWork W1993764875 @default.
- W2080321337 hasRelatedWork W2013243191 @default.
- W2080321337 hasRelatedWork W2046158694 @default.
- W2080321337 hasRelatedWork W2082860237 @default.
- W2080321337 hasRelatedWork W2130076355 @default.
- W2080321337 hasRelatedWork W2151865869 @default.
- W2080321337 hasRelatedWork W2748952813 @default.
- W2080321337 hasRelatedWork W2899084033 @default.
- W2080321337 hasVolume "110" @default.
- W2080321337 isParatext "false" @default.
- W2080321337 isRetracted "false" @default.
- W2080321337 magId "2080321337" @default.
- W2080321337 workType "article" @default.