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- W2080321397 endingPage "75" @default.
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- W2080321397 abstract "Excitation-contraction coupling in both skeletal and cardiac muscle depends on structural and functional interactions between the voltage-sensing dihydropyridine receptor L-type Ca(2+) channels in the surface/transverse tubular membrane and ryanodine receptor Ca(2+) release channels in the sarcoplasmic reticulum membrane. The channels are targeted to either side of a narrow junctional gap that separates the external and internal membrane systems and are arranged so that bi-directional structural and functional coupling can occur between the proteins. There is strong evidence for a physical interaction between the two types of channel protein in skeletal muscle. This evidence is derived from studies of excitation-contraction coupling in intact myocytes and from experiments in isolated systems where fragments of the dihydropyridine receptor can bind to the ryanodine receptors in sarcoplasmic reticulum vesicles or in lipid bilayers and alter channel activity. Although micro-regions that participate in the functional interactions have been identified in each protein, the role of these regions and the molecular nature of the protein-protein interaction remain unknown. The trigger for Ca(2+) release through ryanodine receptors in cardiac muscle is a Ca(2+) influx through the L-type Ca(2+) channel. The Ca(2+) entering through the surface membrane Ca(2+) channels flows directly onto underlying ryanodine receptors and activates the channels. This was thought to be a relatively simple system compared with that in skeletal muscle. However, complexities are emerging and evidence has now been obtained for a bi-directional physical coupling between the proteins in cardiac as well as skeletal muscle. The molecular nature of this coupling remains to be elucidated." @default.
- W2080321397 created "2016-06-24" @default.
- W2080321397 creator A5014130762 @default.
- W2080321397 creator A5026126938 @default.
- W2080321397 creator A5049563006 @default.
- W2080321397 creator A5059624461 @default.
- W2080321397 creator A5073029658 @default.
- W2080321397 creator A5085253794 @default.
- W2080321397 date "2002-05-01" @default.
- W2080321397 modified "2023-09-26" @default.
- W2080321397 title "Interactions between dihydropyridine receptors and ryanodine receptors in striated muscle" @default.
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