Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080321520> ?p ?o ?g. }
- W2080321520 endingPage "215" @default.
- W2080321520 startingPage "206" @default.
- W2080321520 abstract "The assembly of a collection of gene-expression signatures of the major types of B-cell non-Hodgkin's lymphoma has identified increased T-cell leukemia/lymphoma 1A (TCL1) expression in multiple lymphoma types and cases, and has enabled the investigation of the functional and clinical importance of TCL1 expression. Specifically, Burkitt's lymphoma cases show a homogeneously strong expression of TCL1, whereas diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, chronic lymphocytic leukemia, nodal marginal zone lymphoma, and splenic marginal zone lymphoma display a striking variability in the intensity of TCL1 staining. This was validated in two independent series. A Gene-Set Enrichment Analysis of the genes correlated with TCL1A expression found that variation in the level of expression of TCL1A was significantly associated with some of the most important gene signatures recognizing B-cell lymphoma pathogenesis and heterogeneity, such as germinal center, B-cell receptor, NF-kappaB (and its target genes), death, MAP kinases, TNFR1, TOLL, and IL1R. Additionally, TCL1 expression was correlated with shorter time to treatment in chronic lymphocytic leukemia cases and shorter lymphoma-specific survival in mantle cell lymphoma series, thus indicating the clinical and biological significance of TCL1 expression, and suggesting TCL1A as a potential therapeutic target." @default.
- W2080321520 created "2016-06-24" @default.
- W2080321520 creator A5012928732 @default.
- W2080321520 creator A5021107350 @default.
- W2080321520 creator A5041293621 @default.
- W2080321520 creator A5045400339 @default.
- W2080321520 creator A5047736157 @default.
- W2080321520 creator A5061248340 @default.
- W2080321520 creator A5065902991 @default.
- W2080321520 creator A5068246622 @default.
- W2080321520 creator A5070411650 @default.
- W2080321520 creator A5074244429 @default.
- W2080321520 creator A5079168682 @default.
- W2080321520 creator A5080867901 @default.
- W2080321520 creator A5083925677 @default.
- W2080321520 creator A5085867704 @default.
- W2080321520 creator A5089694902 @default.
- W2080321520 date "2008-09-26" @default.
- W2080321520 modified "2023-10-16" @default.
- W2080321520 title "TCL1A expression delineates biological and clinical variability in B-cell lymphoma" @default.
- W2080321520 cites W1514488017 @default.
- W2080321520 cites W1966483883 @default.
- W2080321520 cites W1977193819 @default.
- W2080321520 cites W1988377311 @default.
- W2080321520 cites W2005420970 @default.
- W2080321520 cites W2025057435 @default.
- W2080321520 cites W2026496528 @default.
- W2080321520 cites W2038476365 @default.
- W2080321520 cites W2049090395 @default.
- W2080321520 cites W2050440493 @default.
- W2080321520 cites W2052840083 @default.
- W2080321520 cites W2054246361 @default.
- W2080321520 cites W2067554305 @default.
- W2080321520 cites W2069386297 @default.
- W2080321520 cites W2073746138 @default.
- W2080321520 cites W2074791128 @default.
- W2080321520 cites W2091213817 @default.
- W2080321520 cites W2099042353 @default.
- W2080321520 cites W2104030929 @default.
- W2080321520 cites W2105066639 @default.
- W2080321520 cites W2107202569 @default.
- W2080321520 cites W2119417464 @default.
- W2080321520 cites W2123045903 @default.
- W2080321520 cites W2123613307 @default.
- W2080321520 cites W2137301785 @default.
- W2080321520 cites W2140850833 @default.
- W2080321520 cites W2147246240 @default.
- W2080321520 cites W2147979002 @default.
- W2080321520 cites W2161409973 @default.
- W2080321520 cites W4250894669 @default.
- W2080321520 cites W4256341283 @default.
- W2080321520 doi "https://doi.org/10.1038/modpathol.2008.148" @default.
- W2080321520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18820675" @default.
- W2080321520 hasPublicationYear "2008" @default.
- W2080321520 type Work @default.
- W2080321520 sameAs 2080321520 @default.
- W2080321520 citedByCount "43" @default.
- W2080321520 countsByYear W20803215202012 @default.
- W2080321520 countsByYear W20803215202013 @default.
- W2080321520 countsByYear W20803215202014 @default.
- W2080321520 countsByYear W20803215202015 @default.
- W2080321520 countsByYear W20803215202016 @default.
- W2080321520 countsByYear W20803215202017 @default.
- W2080321520 countsByYear W20803215202019 @default.
- W2080321520 countsByYear W20803215202021 @default.
- W2080321520 countsByYear W20803215202022 @default.
- W2080321520 countsByYear W20803215202023 @default.
- W2080321520 crossrefType "journal-article" @default.
- W2080321520 hasAuthorship W2080321520A5012928732 @default.
- W2080321520 hasAuthorship W2080321520A5021107350 @default.
- W2080321520 hasAuthorship W2080321520A5041293621 @default.
- W2080321520 hasAuthorship W2080321520A5045400339 @default.
- W2080321520 hasAuthorship W2080321520A5047736157 @default.
- W2080321520 hasAuthorship W2080321520A5061248340 @default.
- W2080321520 hasAuthorship W2080321520A5065902991 @default.
- W2080321520 hasAuthorship W2080321520A5068246622 @default.
- W2080321520 hasAuthorship W2080321520A5070411650 @default.
- W2080321520 hasAuthorship W2080321520A5074244429 @default.
- W2080321520 hasAuthorship W2080321520A5079168682 @default.
- W2080321520 hasAuthorship W2080321520A5080867901 @default.
- W2080321520 hasAuthorship W2080321520A5083925677 @default.
- W2080321520 hasAuthorship W2080321520A5085867704 @default.
- W2080321520 hasAuthorship W2080321520A5089694902 @default.
- W2080321520 hasBestOaLocation W20803215201 @default.
- W2080321520 hasConcept C107006841 @default.
- W2080321520 hasConcept C142724271 @default.
- W2080321520 hasConcept C159654299 @default.
- W2080321520 hasConcept C203014093 @default.
- W2080321520 hasConcept C2777058707 @default.
- W2080321520 hasConcept C2777172399 @default.
- W2080321520 hasConcept C2777525834 @default.
- W2080321520 hasConcept C2777938653 @default.
- W2080321520 hasConcept C2778453870 @default.
- W2080321520 hasConcept C2778461978 @default.
- W2080321520 hasConcept C2779338263 @default.
- W2080321520 hasConcept C2779380147 @default.
- W2080321520 hasConcept C2779921676 @default.
- W2080321520 hasConcept C2780653079 @default.